Steinberg S, Dehring D, Martin D, Gower W, Carey L, Cloutier C
Department of Surgery, Ohio State University College of Medicine, Columbus.
J Trauma. 1987 Dec;27(12):1323-31. doi: 10.1097/00005373-198712000-00002.
The effects of sulindac, a cyclo-oxygenase inhibitor, were tested in a bacteremic porcine model of acute respiratory failure produced by a continuous infusion of live Pseudomonas aeruginosa. Control groups received either a single intravenous dose of sulindac (6 mg/kg) 20 minutes after baseline determinations or a continuous infusion of Ps. aeruginosa (10(7) CFU/kg/min) beginning at time 0. The experimental group received both. Sulindac alone had no effect on any hemodynamic or gas exchange parameter. Ps. aeruginosa infusion caused pulmonary hypertension, hypoxemia, increased intrapulmonary shunt fraction, systemic hypotension, and increased extravascular lung water. Sulindac treatment reversed the pulmonary hypertension, hypoxemia, and increased intrapulmonary shunting, prevented the systemic hypotension, but had no effect on the rising extravascular lung water.
在通过持续输注活的铜绿假单胞菌建立的急性呼吸衰竭菌血症猪模型中，测试了环氧化酶抑制剂舒林酸的效果。对照组在基线测定后20分钟接受单次静脉注射舒林酸（6毫克/千克），或从0时刻开始持续输注铜绿假单胞菌（10⁷ 菌落形成单位/千克/分钟）。实验组同时接受这两种处理。单独使用舒林酸对任何血流动力学或气体交换参数均无影响。输注铜绿假单胞菌导致肺动脉高压、低氧血症、肺内分流分数增加、全身低血压以及血管外肺水增加。舒林酸治疗可逆转肺动脉高压、低氧血症和肺内分流增加，预防全身低血压，但对血管外肺水增加没有影响。
