Altern Ther Health Med. 2023 May;29(4):210-217.
In recent years, the number of women with unexplained infertility has increased, and clinicians consider poor endometrial receptivity (ER) to be one of the main reasons. ER can have great predictive value for in-vitro fertilization embryo transfer (IVF-ET)-induced pregnancy.
The study intended to investigate the predictive value of ER-endometrial thickness (EMT) and type and hemodynamic parameters-using color-doppler ultrasound on the pregnancy outcome of IVF-ET for women of different ages.
The research team performed a prospective controlled study.
The study took place at the Department of Reproductive Medicine at Hebei Reproductive Hospital in Shijiazhuang, China.
Participants were 841 infertile patients undergoing IVF-ET treatment at the hospital between March 01, 2018 and December 30, 2018. The research team divided participants into two groups: (1) participants diagnosed as having a clinical pregnancy after IVF-ET became the pregnancy group, with 439 participants, and (2) participants who didn't become pregnant became the nonpregnancy group, with 402 participants.
The research team: (1) measured EMT, (2) determined endometrium types, (3) classified the intimal and subintimal blood flow, and (4) determined the hemodynamic parameters of the endometrium and subendometrium. The team also measured: (1) the systolic blood flow velocity (VS), (2) diastolic blood flow velocity (VD), and (3) average blood flow velocity (VM) three times and recorded the average value.
Statistically significant differences existed in the pregnancy and implantation rates among the different age groups for the groups with EMTs of <8 mm and 8-13 mm (P < .05). The results were similar in the endometrial Type A and endometrial Type B groups as well as between the endometrial blood flow Type 1 and Type 2 groups (P < .05). The distribution of endometrial blood flow types was significantly different between the groups (P = .002). In addition, statistically significant differences existed in the implantation rates between the <30 years and 30-34 groups in different blood-flow-type groups (P < .05). Based on the results of the ROC curve, high-quality embryos (0.566, 95%CI: 0.527-0.605) and endometrial blood flow types (0.554, 95%CI: 0.515-0.593) could not predict clinical pregnancy.
The pregnancy and implantation rates increased between the <30 and 30-34 age groups and them decreased between the age groups as age increased. EMT, endometrial type, and blood flow type can be valuable parameters in predicting the implantation and pregnancy rates of patients of different ages.
近年来，不明原因不孕的女性数量有所增加，临床医生认为子宫内膜容受性（ER）差是主要原因之一。ER 对体外受精胚胎移植（IVF-ET）诱导妊娠具有很好的预测价值。
本研究旨在探讨 ER-子宫内膜厚度（EMT）和类型以及血流参数-使用彩色多普勒超声对不同年龄妇女 IVF-ET 妊娠结局的预测价值。
研究团队进行了一项前瞻性对照研究。
研究地点位于中国石家庄市河北生殖妇产医院生殖医学科。
参与者为 2018 年 3 月 1 日至 2018 年 12 月 30 日在医院接受 IVF-ET 治疗的 841 名不孕患者。研究团队将参与者分为两组：（1）IVF-ET 后临床妊娠诊断为妊娠组，有 439 名参与者；（2）未妊娠的参与者为非妊娠组，有 402 名参与者。
研究团队：（1）测量 EMT；（2）确定子宫内膜类型；（3）分类内膜和内膜下血流；（4）测量子宫内膜和内膜下的血流动力学参数。还测量了：（1）收缩期血流速度（VS）；（2）舒张期血流速度（VD）；（3）平均血流速度（VM），并记录平均值。
对于 EMT＜8mm 和 8-13mm 的组，不同年龄组的妊娠率和着床率存在统计学差异（P＜0.05）。子宫内膜 A 型和 B 型组以及子宫内膜血流 1 型和 2 型组之间的结果也相似（P＜0.05）。组间子宫内膜血流类型的分布差异有统计学意义（P=0.002）。此外，不同血流类型组中，＜30 岁和 30-34 岁组的着床率存在统计学差异（P＜0.05）。基于 ROC 曲线的结果，优质胚胎（0.566，95%CI：0.527-0.605）和子宫内膜血流类型（0.554，95%CI：0.515-0.593）不能预测临床妊娠。
＜30 岁和 30-34 岁年龄组的妊娠率和着床率增加，而年龄组增加时妊娠率和着床率下降。EMT、子宫内膜类型和血流类型可作为预测不同年龄患者种植率和妊娠率的有价值参数。
