棕榈酸水平升高可导致胎儿先天性心脏病
Increased gestational palmitic acid predisposes offspring to congenital heart disease.
机构信息
Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
出版信息
Cell Rep Med. 2023 Mar 21;4(3):100984. doi: 10.1016/j.xcrm.2023.100984.
Abstract
Identification of the causes for congenital heart disease (CHD) is a prerequisite for precise prevention and personalized treatment of CHD. Zhao et al. show increased that gestational serum palmitic acid (PA) predisposes offspring to CHD by perturbating the MARS/K-Hcy/GATA4 signaling pathway.
摘要
鉴定先天性心脏病（CHD）的病因是精准预防和个性化治疗 CHD 的前提。Zhao 等人表明，妊娠血清棕榈酸（PA）通过扰乱 MARS/K-Hcy/GATA4 信号通路，增加了后代患 CHD 的风险。
Zotero 插件