Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China.
Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510030, PR China.
Diabetes Res Clin Pract. 2023 May;199:110629. doi: 10.1016/j.diabres.2023.110629. Epub 2023 Mar 21.
Whether type 1 diabetes mellitus (T1DM) could be regarded as an independent risk factor for atrial fibrillation (AF) risk remains unclear, and thus we aimed to elaborate on this association in our meta-analysis.
We systematically searched the Pubmed, Embase, Cochrane Library and Web of Science databases up to August 2022 for studies that were related to T1DM and AF incidence. Hazard ratios (HRs) and 95% confidence intervals (CIs) from each study were pooled via a random-effects model.
A total of four cohort studies were involved in our meta-analysis. Our pooled results suggested that T1DM patients had a higher AF risk (HR = 1.30, 95%CI 1.15-1.47) than the control group. In the subgroup analysis, a higher AF incidence was also found in female T1DM patients (HR = 1.50, 95%CI 1.26-1.79) than that in male patients. Compared with T1DM patients over 65 years, those with < 65 years showed an increased risk of AF (HR = 1.45, 95%CI 1.21-1.74).
Our meta-analysis demonstrated that T1DM was an independent risk factor for AF development, but further studies should be performed to provide more convincing evidence.
1 型糖尿病（T1DM）是否可以视为房颤（AF）风险的独立危险因素尚不清楚，因此我们旨在通过荟萃分析来阐述这种相关性。
我们系统地检索了 Pubmed、Embase、Cochrane Library 和 Web of Science 数据库，截至 2022 年 8 月，以获取与 T1DM 和 AF 发生率相关的研究。通过随机效应模型对每项研究的风险比（HR）和 95%置信区间（CI）进行合并。
共有四项队列研究纳入了我们的荟萃分析。我们的汇总结果表明，T1DM 患者发生 AF 的风险更高（HR=1.30，95%CI 1.15-1.47）。在亚组分析中，女性 T1DM 患者（HR=1.50，95%CI 1.26-1.79）比男性患者发生 AF 的风险更高。与年龄>65 岁的 T1DM 患者相比，年龄<65 岁的患者发生 AF 的风险增加（HR=1.45，95%CI 1.21-1.74）。
我们的荟萃分析表明，T1DM 是 AF 发生的独立危险因素，但需要进一步的研究来提供更有说服力的证据。
