Fosl1：朋友还是敌人？

Fosl1: friend or foe?

机构信息

Institute of Molecular Cardiovascular Research, Medical Faculty, RWTH Aachen University, Aachen, Germany.

Institute of Molecular Cardiovascular Research, Medical Faculty, RWTH Aachen University, Aachen, Germany; Experimental Vascular Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, the Netherlands; Aachen Maastricht Institute for Cardiorenal Research (AMICARE), RWTH Aachen University, Aachen, Germany.

出版信息

Kidney Int. 2023 Apr;103(4):656-658. doi: 10.1016/j.kint.2022.12.019.

DOI:10.1016/j.kint.2022.12.019

PMID:36948764

Abstract

Fos-like antigen 1 (Fosl1) is a protein that belongs to the Fos family of transcription factors. Fosl1 has an impact on (i) carcinogenesis, (ii) acute kidney injury, and (iii) fibroblast growth factor expression. Recently, the nephroprotective effect of Fosl1 by the preservation of Klotho expression was recently identified. The identification of a link between Fosl1 and Klotho expression provides an entirely new field of nephroprotection.

摘要

Fos 样抗原 1（Fosl1）是一种属于转录因子 Fos 家族的蛋白质。Fosl1 对（i）致癌作用、（ii）急性肾损伤和（iii）成纤维细胞生长因子表达有影响。最近，通过 Klotho 表达的保存，发现了 Fosl1 的肾保护作用。Fosl1 与 Klotho 表达之间的联系的鉴定为肾保护提供了一个全新的领域。