当清洁促进混乱时——纤毛虫中的基因组编辑。
When cleaning facilitates cluttering - genome editing in ciliates.
机构信息
Max Planck Institute for Biology, 72076 Tübingen, Germany.
Max Planck Institute for Biology, 72076 Tübingen, Germany.
出版信息
Trends Genet. 2023 May;39(5):344-346. doi: 10.1016/j.tig.2023.02.016. Epub 2023 Mar 21.
PMID:36949004
Abstract
Many organisms remove DNA from their genomes during development. This has foremost been characterized as a means of defending genomes against mobile elements. However, genome editing actually hides such elements from purifying selection, with the survivors evolving approximately neutrally, 'cluttering' the germline genome, enabling it to enlarge over time.
摘要
许多生物在发育过程中会从基因组中删除 DNA。这首先被认为是一种保护基因组免受移动元件侵害的手段。然而，基因组编辑实际上将这些元件隐藏在净化选择之外，使它们以近似中性的方式进化，“使生殖系基因组混乱”，从而使基因组能够随着时间的推移而扩大。
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