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The potential contribution of in silico studies to improved treatment of osteoarthritis.

作者信息

van Donkelaar Corrinus C

机构信息

Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.

出版信息

Nat Rev Rheumatol. 2023 May;19(5):261-262. doi: 10.1038/s41584-023-00953-1.

DOI:10.1038/s41584-023-00953-1
PMID:36949105
Abstract
摘要

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The potential contribution of in silico studies to improved treatment of osteoarthritis.计算机模拟研究对改善骨关节炎治疗的潜在贡献。
Nat Rev Rheumatol. 2023 May;19(5):261-262. doi: 10.1038/s41584-023-00953-1.
2
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[Peripheral arthritis in family practice].
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Should osteoarthritis be treated with nonsteroidal anti-inflammatory drugs?骨关节炎应该用非甾体抗炎药治疗吗？
Rheum Dis Clin North Am. 1993 Aug;19(3):697-712.
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Therapeutic effect of intra-articular injection of high molecular weight hyaluronic acid on osteoarthritis of the knee.关节腔内注射高分子量透明质酸对膝骨关节炎的治疗作用。
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Topical herbal therapies for treating osteoarthritis.用于治疗骨关节炎的局部草药疗法。
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8
Homoeopathic treatment of osteoarthritis.
Lancet. 1983 Feb 5;1(8319):304-5.
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[Social impact of osteoarthritis. Risk/benefit--cost/effectiveness ratio of osteoarthritis treatments].
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[Symptomatic slow-acting drugs in the treatment of osteoarthritis: focus on glucosamine preparations].
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本文引用的文献

1
Contribution of collagen degradation and proteoglycan depletion to cartilage degeneration in primary and secondary osteoarthritis: an in silico study.原发性和继发性骨关节炎中胶原降解和蛋白聚糖耗竭对软骨退化的贡献：一项计算机模拟研究。
Osteoarthritis Cartilage. 2023 Jun;31(6):741-752. doi: 10.1016/j.joca.2023.01.004. Epub 2023 Jan 18.
2
An Framework of Cartilage Degeneration That Integrates Fibril Reorientation and Degradation Along With Altered Hydration and Fixed Charge Density Loss.一个整合了原纤维重新定向、降解以及水合作用改变和固定电荷密度损失的软骨退变框架。
Front Bioeng Biotechnol. 2021 Jun 22;9:680257. doi: 10.3389/fbioe.2021.680257. eCollection 2021.
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Spectroscopic photoacoustic imaging of cartilage damage.
软骨损伤的光谱光声成像
Osteoarthritis Cartilage. 2021 Jul;29(7):1071-1080. doi: 10.1016/j.joca.2021.04.001. Epub 2021 Apr 11.
4
How a decreased fibrillar interconnectivity influences stiffness and swelling properties during early cartilage degeneration.在早期软骨退变过程中，纤维连接减少如何影响硬度和肿胀特性。
J Mech Behav Biomed Mater. 2017 Nov;75:390-398. doi: 10.1016/j.jmbbm.2017.07.042. Epub 2017 Aug 3.
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A Novel Method to Simulate the Progression of Collagen Degeneration of Cartilage in the Knee: Data from the Osteoarthritis Initiative.一种模拟膝关节软骨胶原退变进展的新方法：来自骨关节炎倡议组织的数据。
Sci Rep. 2016 Feb 24;6:21415. doi: 10.1038/srep21415.
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A numerical model to study mechanically induced initiation and progression of damage in articular cartilage.用于研究关节软骨中机械诱导损伤起始和进展的数值模型。
Osteoarthritis Cartilage. 2014 Jan;22(1):95-103. doi: 10.1016/j.joca.2013.10.010. Epub 2013 Nov 1.
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A composition-based cartilage model for the assessment of compositional changes during cartilage damage and adaptation.一种基于成分的软骨模型，用于评估软骨损伤和适应过程中的成分变化。
Osteoarthritis Cartilage. 2006 Jun;14(6):554-60. doi: 10.1016/j.joca.2005.12.006. Epub 2006 Feb 13.
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Strain-controlled enzymatic cleavage of collagen in loaded matrix.负载基质中胶原的应变控制酶解。
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Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression.
Arch Biochem Biophys. 2003 Sep 1;417(1):105-11. doi: 10.1016/s0003-9861(03)00340-0.