伴刀豆球蛋白A对皮肤成纤维细胞中低密度脂蛋白代谢影响的研究。
Studies on the effect of concanavalin A on the metabolism of low density lipoproteins in skin fibroblasts.
作者信息
Matsuura H, Ranganathan S, Yamamoto M, Kattke B A
机构信息
Atherosclerosis Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905.
出版信息
Jpn J Med. 1987 Aug;26(3):323-5. doi: 10.2169/internalmedicine1962.26.323.
Concanavalin A bound to the cell surface decreased the binding and internalization of low density lipoproteins (LDL) to human skin fibroblasts. However, concanavalin A failed to inhibit the degradation of preinternalized LDL. Concanavalin A inhibited the activation of acyl-CoA: cholesterol acyltransferase by LDL. These results strongly suggest that concanavalin A inhibits the metabolism of LDL in human skin fibroblasts by affecting the receptor binding and internalization of LDL.
结合到细胞表面的伴刀豆球蛋白A降低了低密度脂蛋白（LDL）与人皮肤成纤维细胞的结合及内化。然而，伴刀豆球蛋白A未能抑制内化前LDL的降解。伴刀豆球蛋白A抑制了LDL对酰基辅酶A：胆固醇酰基转移酶的激活作用。这些结果有力地表明，伴刀豆球蛋白A通过影响LDL的受体结合及内化来抑制人皮肤成纤维细胞中LDL的代谢。
Zotero 插件