Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, OH, USA.
Department of Nephrology, Akron Children's Hospital, Akron, OH, USA.
Pediatr Res. 2023 Oct;94(4):1385-1391. doi: 10.1038/s41390-023-02564-8. Epub 2023 Mar 22.
Hospitalized children with acute kidney injury (AKI) have not been extensively studied for clinical outcomes including hospital stay, the need for mechanical ventilation, mortality rates, and healthcare utilization. We hypothesize significant financial costs and increased morbidity and mortality associated with pediatric AKI.
This is a retrospective study of pediatric patients (age ≤18 years) included in the Kids' Inpatient Database (KID) between January 1, 2016, and December 31, 2021. The results of the data analysis were utilized for comparative testing between the AKI and non-AKI cohorts.
The study included 4842 children [with AKI (n = 2424) and without AKI (n = 2418)]. The odds of mortality (p = 0.004) and mechanical ventilation (p < 0.001) were observed to be significantly higher among those with AKI as compared to those without AKI. Additionally, the median (IQR) duration of stay in the hospital (p < 0.001) and total cost (p < 0.001) were significantly higher among those with AKI vs. those without AKI.
AKI in children was associated with higher odds of mortality, longer duration of hospital stay, increased requirement of mechanical ventilation, and increased hospital expenditure. The scientific community can utilize this information to better understand the outcomes associated with this disease process in this patient population.
This article has thoroughly evaluated epidemiologic data associated with pediatric acute kidney injury (AKI) in hospitalized patients This study assesses mortality, hospital expenditure, and other factors to strengthen single-center and few multi-center studies and provides novel data regarding insurance and cost associated with pediatric AKI With increased knowledge of current epidemiology and risk factors, the scientific community can better understand prevention and outcomes in hospitalized children with AKI.
急性肾损伤（AKI）住院患儿的临床结局，包括住院时间、机械通气需求、死亡率和医疗保健利用，尚未得到广泛研究。我们假设与儿科 AKI 相关的医疗费用显著增加以及发病率和死亡率增加。
这是一项回顾性研究，纳入了 2016 年 1 月 1 日至 2021 年 12 月 31 日期间 Kid's Inpatient Database（KID）中的儿科患者（年龄≤18 岁）。数据分析结果用于 AKI 组和非 AKI 组之间的比较测试。
该研究纳入了 4842 名儿童[AKI（n=2424）和非 AKI（n=2418）]。与非 AKI 组相比，AKI 组的死亡率（p=0.004）和机械通气（p<0.001）的几率更高。此外，AKI 组的住院时间中位数（IQR）（p<0.001）和总费用（p<0.001）均显著高于非 AKI 组。
儿童 AKI 与死亡率增加、住院时间延长、机械通气需求增加和住院费用增加有关。科学界可以利用这些信息更好地了解该疾病过程在该患者人群中的结局。
本文详细评估了住院患儿的儿科急性肾损伤（AKI）相关流行病学数据。本研究评估了死亡率、医院支出和其他因素，以加强单中心和少数多中心研究，并提供了有关儿科 AKI 相关保险和成本的新数据。随着对当前流行病学和危险因素的更多了解，科学界可以更好地理解住院 AKI 患儿的预防和结局。
