原位肝移植后他克莫司诱发的运动不能性缄默症和持续性构音障碍。 - Suppr

Tacrolimus-induced akinetic mutism and persistent dysarthria following orthotopic liver transplantation.

作者信息

Provenzani Alessio, Re Vincenzina Lo

机构信息

Clinical Pharmacy Service, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy.

Neurology Unit, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy.

出版信息

Neurol Sci. 2023 Aug;44(8):2983-2984. doi: 10.1007/s10072-023-06760-6. Epub 2023 Mar 23.

DOI:10.1007/s10072-023-06760-6

PMID:36949300

Abstract

摘要

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Tacrolimus-induced akinetic mutism and persistent dysarthria following orthotopic liver transplantation.原位肝移植后他克莫司诱发的运动不能性缄默症和持续性构音障碍。

Neurol Sci. 2023 Aug;44(8):2983-2984. doi: 10.1007/s10072-023-06760-6. Epub 2023 Mar 23.

Akinetic mutism induced by tacrolimus.他克莫司诱发的运动不能性缄默症。

Clin Neuropharmacol. 2009 Sep-Oct;32(5):293-4. doi: 10.1097/WNF.0b013e3181a77fab.

Mutism and persistent dysarthria due to tacrolimus-based immunosuppression following allogeneic liver transplantation.他克莫司免疫抑制致肝移植后缄默症和持续性构音障碍。

Am J Ther. 2011 Nov;18(6):e274-6. doi: 10.1097/MJT.0b013e3181debc6f.

Reversible acute encephalopathy with mutism, induced by calcineurin inhibitors after renal transplantation.钙调磷酸酶抑制剂诱导的肾移植术后可逆性缄默性急性脑病。

J Nephrol. 2012 Sep-Oct;25(5):839-42. doi: 10.5301/jn.5000080.

Akinetic mutism-a serious complication to tacrolimus-based GVHD prophylaxis.

Bone Marrow Transplant. 2013 Jan;48(1):157-8. doi: 10.1038/bmt.2012.110. Epub 2012 Jun 18.

Dysarthria and apraxia of speech associated with FK-506 (tacrolimus).与FK-506（他克莫司）相关的构音障碍和言语失用症。

Mayo Clin Proc. 1996 Oct;71(10):969-72.

Tacrolimus (FK506)-induced mutism after liver transplant.肝移植后他克莫司（FK506）诱发的缄默症。

Pediatr Neurol. 2003 Feb;28(2):156-8. doi: 10.1016/s0887-8994(02)00502-7.

Tacrolimus-Induced Akinetic Mutism or Epidural Catheter Migration: A Case Report.他克莫司致无动性缄默症或硬膜外导管迁移：1 例报告。

A A Pract. 2023 Jul 18;17(7):e01699. doi: 10.1213/XAA.0000000000001699. eCollection 2023 Jul 1.

Catatonic mutism after liver transplant rapidly reversed with lorazepam.

Gen Hosp Psychiatry. 2007 May-Jun;29(3):280-1. doi: 10.1016/j.genhosppsych.2007.01.004.

Tacrolimus-associated mutism after orthotopic liver transplantation.

Transplantation. 2000 Sep 27;70(6):979-82. doi: 10.1097/00007890-200009270-00017.

引用本文的文献

Rapidly progressive dementia in tacrolimus neurotoxicity: rare but reversible.他克莫司神经毒性所致的快速进展性痴呆：罕见但可逆转。

Neurol Sci. 2025 May 23. doi: 10.1007/s10072-025-08248-x.

Tacrolimus-Induced Neurotoxicity After Transplant: A Literature Review.他克莫司致移植后神经毒性：文献综述。

Drug Saf. 2024 May;47(5):419-438. doi: 10.1007/s40264-024-01398-5. Epub 2024 Feb 14.

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Tacrolimus-induced neurotoxicity from bipolar disorder to status epilepticus under the therapeutic serum level: a case report.环孢素诱导的神经毒性：从双相情感障碍到治疗血清水平下的癫痫持续状态：病例报告。

BMC Neurol. 2021 Nov 15;21(1):448. doi: 10.1186/s12883-021-02479-z.

Tacrolimus neurotoxicity and the role of the Renin-Angiotensin system.

J Neuropsychiatry Clin Neurosci. 2015;27(2):e140-1. doi: 10.1176/appi.neuropsych.14010011.

Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients.肝、肾移植患者中环孢素剂量优化的药物遗传学考虑因素。

World J Gastroenterol. 2013 Dec 28;19(48):9156-73. doi: 10.3748/wjg.v19.i48.9156.

Akinetic mutism-a serious complication to tacrolimus-based GVHD prophylaxis.

Bone Marrow Transplant. 2013 Jan;48(1):157-8. doi: 10.1038/bmt.2012.110. Epub 2012 Jun 18.

Mutism and persistent dysarthria due to tacrolimus-based immunosuppression following allogeneic liver transplantation.他克莫司免疫抑制致肝移植后缄默症和持续性构音障碍。

Am J Ther. 2011 Nov;18(6):e274-6. doi: 10.1097/MJT.0b013e3181debc6f.

Akinetic mutism induced by tacrolimus.他克莫司诱发的运动不能性缄默症。

Clin Neuropharmacol. 2009 Sep-Oct;32(5):293-4. doi: 10.1097/WNF.0b013e3181a77fab.

Neurotoxicity of immunosuppressive drugs.免疫抑制药物的神经毒性。

Liver Transpl. 2001 Nov;7(11):937-42. doi: 10.1053/jlts.2001.27475.

Dysarthria and apraxia of speech associated with FK-506 (tacrolimus).与FK-506（他克莫司）相关的构音障碍和言语失用症。

Mayo Clin Proc. 1996 Oct;71(10):969-72.

A method for estimating the probability of adverse drug reactions.一种估算药物不良反应概率的方法。

Clin Pharmacol Ther. 1981 Aug;30(2):239-45. doi: 10.1038/clpt.1981.154.

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Tacrolimus-induced akinetic mutism and persistent dysarthria following orthotopic liver transplantation.

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