家族性腺瘤性息肉病患者结肠切除标本中的偶发癌：单中心经验及文献复习。

Incidental cancer in colectomy specimens from patients with familial adenomatous polyposis: single centre experience and literature review.

机构信息

General Surgery Department, Health Sciences University Izmir Tepecik Education and Research Hospital, Izmir, Turkey.

General Surgery Department, Baskent University Adana Dr. Turgut Noyan Training and Research Hospital, Adana, Turkey.

出版信息

Int J Colorectal Dis. 2023 Mar 23;38(1):76. doi: 10.1007/s00384-023-04370-4.

DOI:10.1007/s00384-023-04370-4

PMID:36949302

Abstract

BACKGROUND

Since cancer development is inevitable in patients with familial adenomatous polyposis (FAP), we aimed to determine the incidence of incidental malignancy in prophylactic colectomy specimens.

METHODS

The files of patients who underwent prophylactic surgery for FAP between 2010 and 2020 were retrospectively reviewed. The incidence of incidental malignancy in histopathological specimens was examined and a comprehensive literature review was made.

RESULTS

Fifty-five patients were included in the study, of whom 30 patients had a diagnosis of primary malignancy. Prophylactic colectomy was performed on 25 patients. The pathology results indicated that the specimens were benign in 12 patients (48%) and revealed carcinoma in situ in 11 patients (44%). Incidental malignancy was detected in 2 patients (8%). In the literature review, there were 243 patients who underwent prophylactic colectomy and incidental cancer was detected in 25 patients (10.3%) with the stages of 1 (7.4%), 2 (2.1%), and 3 (0.8%), respectively.

CONCLUSIONS

Incidental cancer is not rare in patients who have undergone prophylactic colectomy for FAP. Hopefully. they are usually at early stages and unexpected advanced cancers are seen rarely.

摘要

背景

由于家族性腺瘤性息肉病（FAP）患者不可避免地会发展为癌症，我们旨在确定预防性结肠切除术标本中偶然恶性肿瘤的发生率。

方法

回顾性分析了 2010 年至 2020 年期间因 FAP 而行预防性手术的患者的病历。检查了组织病理学标本中偶然恶性肿瘤的发生率，并进行了全面的文献复习。

结果

本研究纳入了 55 名患者，其中 30 名患者被诊断为原发性恶性肿瘤。对 25 名患者进行了预防性结肠切除术。12 名患者（48%）的病理结果为良性，11 名患者（44%）为原位癌。2 名患者（8%）检测到偶然恶性肿瘤。在文献复习中，有 243 名患者接受了预防性结肠切除术，25 名患者（10.3%）检测到偶然癌症，分期分别为 1 期（7.4%）、2 期（2.1%）和 3 期（0.8%）。