Department of Psychology, Institute of Psychology, Psychiatry and Neuroscience, King's College London, DeCrespigny Park, London, SE5 8AF, UK.
Department of Psychological Medicine, Institute of Psychology, Psychiatry and Neuroscience, King's College London, DeCrespigny Park, London, SE5 8AF, UK.
Bipolar Disord. 2023 Jun;25(4):278-288. doi: 10.1111/bdi.13322. Epub 2023 Apr 2.
Several studies have suggested that anxiety disorders in childhood and adolescence often precede the onset of bipolar disorder. We therefore systematically reviewed the relationship between child and adolescent anxiety and later bipolar disorder.
Online databases (Medline [for Ovid], EMBASE and PsychINFO) were searched for original, peer-reviewed studies examining the relationship between child and adolescent anxiety and later bipolar disorder. Studies in both community samples and bipolar offspring samples were included.
A total of 16 studies were included in the review. The results were broadly consistent and revealed that child and adolescent anxiety disorders are associated with later bipolar disorder in community samples. In bipolar offspring, child and adolescent anxiety disorders are a marker of increased risk and predict the onset of bipolar disorder and other major mood disorders.
There is evidence that anxiety disorders in childhood and adolescence increase the risk of later bipolar disorder. Anxiety disorders may be a useful target for early intervention in those at high-risk of bipolar disorder.
多项研究表明，儿童和青少年时期的焦虑障碍往往先于双相情感障碍的发生。因此，我们系统地回顾了儿童和青少年焦虑与随后发生双相情感障碍之间的关系。
在线数据库（Medline [Ovid]、EMBASE 和 PsychINFO）中搜索了原始的、同行评审的研究，这些研究检查了儿童和青少年焦虑与随后发生双相情感障碍之间的关系。包括社区样本和双相情感障碍后代样本的研究。
共有 16 项研究纳入了综述。结果大致一致，表明社区样本中的儿童和青少年焦虑障碍与随后发生的双相情感障碍有关。在双相情感障碍后代中，儿童和青少年焦虑障碍是风险增加的标志，可预测双相情感障碍和其他主要心境障碍的发作。
有证据表明，儿童和青少年时期的焦虑障碍会增加随后发生双相情感障碍的风险。焦虑障碍可能是双相情感障碍高危人群早期干预的一个有用目标。
