Jean Baptiste Wilhermine, Casseus Michelucia, Dev Alka, Joseph Patrice, Wright Peter F
Department of Pediatrics, Dartmouth Hitchcock Medical Center (DHMC), Lebanon, NH, United States.
Department of Pediatrics, Hopital Immacule Conception (HIC), Les Cayes, Haiti.
Front Pediatr. 2023 Mar 6;11:877550. doi: 10.3389/fped.2023.877550. eCollection 2023.
During a 2-year period, eight cases of a distinct illness were seen among 1,424 neonates admitted to a newly established neonatal care unit in southern Haiti. The newborns presented with a picture of sepsis with shock, vomiting, hypotonia, lethargy, and abdominal distention. Five cases proved fatal and another case left the hospital against advice in extremis with little chance of survival. In each case, the illness was associated with a history of ingestion of teas that included castor oil, known as lok in Haitian Creole. The presumptive cause of the illness was established by the presence of a dark, oily substance in drainage from the nares and nasogastric tubes and by subsequent admission on direct questioning of the caregivers, who said that the infants had been given large amounts of lok. The castor oil tea had been given to three infants in the immediate neonatal period where its use is attributed to encouraging the passage of meconium. The five remaining infants were between 15 and 30 days of life when they were given lok shortly before admission to the neonatal unit for treatment of an undefined illness. All of them were term infants with no identified risks at birth. As nasogastric tubes are not routinely placed in sick neonates, and the parents did not volunteer information about lok administration, the practice may be more widespread than that recorded here. Although our data are confined to observations in Haiti, the use of traditional medicines is a globally widespread phenomenon. Attention must be drawn to the potential toxicity of such preparations and means found to ban their use in neonates.
在两年时间里,在海地南部一家新建的新生儿重症监护病房收治的1424名新生儿中,出现了8例一种特殊疾病的病例。这些新生儿表现出败血症伴休克、呕吐、肌张力减退、嗜睡和腹胀的症状。5例死亡,另有1例不顾医生劝阻在极度危急情况下出院,存活几率微乎其微。在每一例中,疾病都与摄入包括蓖麻油(在海地克里奥尔语中称为lok)的茶的病史有关。通过从鼻孔和鼻胃管引流物中发现深色油性物质以及随后直接询问护理人员,他们表示婴儿被喂了大量lok,从而确定了疾病的推测病因。蓖麻油茶在新生儿早期就给了3名婴儿,使用它的原因是认为有助于胎粪排出。其余5名婴儿在出生15至30天之间,在因不明疾病入住新生儿病房前不久被喂了lok。他们都是足月儿,出生时没有确定的风险因素。由于生病的新生儿通常不常规放置鼻胃管,而且家长没有主动提供关于喂lok的信息,这种做法可能比这里记录的更为普遍。虽然我们的数据仅限于在海地的观察,但使用传统药物是一种全球普遍的现象。必须注意此类制剂的潜在毒性,并找到禁止在新生儿中使用它们的方法。