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卵巢间质细胞增生——原发性输卵管癌新辅助化疗后病例中的罕见发现

Leydig Cell Hyperplasia of Ovary - An Unusual Finding in Postneoadjuvant Chemotherapy Case of Primary Fallopian Tube Carcinoma.

作者信息

Chaturvedi Kriti, Rao Meenakshi, Saha Souvik, Vishnoi Jeewan Ram, Nalwa Aasma

机构信息

Department of Pathology and Lab Medicine, AIIMS, Jodhpur, Rajasthan, India.

Department of Surgical Oncology, AIIMS, Jodhpur, Rajasthan, India.

出版信息

J Midlife Health. 2022 Jul-Sep;13(3):247-250. doi: 10.4103/jmh.jmh_117_22. Epub 2023 Jan 14.

DOI:10.4103/jmh.jmh_117_22
PMID:36950208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10025816/
Abstract

A large number of high-grade serous ovarian carcinomas originate in the fallopian tubes. Neoadjuvant chemotherapy followed by surgery may lead to a number of chemotherapy-induced changes in the ovary, which may lead to an erroneous diagnosis. We present a rare case of a 55-year-old postmenopausal woman who was clinically diagnosed with carcinoma of the right ovary; on histopathologic evaluation after neoadjuvant chemotherapy, the primary site was found to be the right fallopian tube. The right ovary showed chemotherapy-related changes along with extensive Leydig cell hyperplasia. As the presence of Leydig cell hyperplasia in this setting is an unusual finding, it may pose a diagnostic dilemma for the pathologist; so an awareness of this entity is important to avoid misdiagnosis.

摘要

大量高级别浆液性卵巢癌起源于输卵管。新辅助化疗后再行手术可能导致卵巢出现一些化疗引起的变化，这可能会导致误诊。我们报告一例罕见病例，一名55岁绝经后女性，临床诊断为右卵巢癌；新辅助化疗后经组织病理学评估，发现原发部位为右侧输卵管。右侧卵巢呈现出与化疗相关的变化以及广泛的Leydig细胞增生。鉴于在这种情况下Leydig细胞增生的存在是一个不寻常的发现，这可能给病理学家带来诊断难题；因此，了解这一实体对于避免误诊很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d609/10025816/22e3f27b1b77/JMH-13-247-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d609/10025816/c0ef8f4f8a34/JMH-13-247-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d609/10025816/3a2db438c9ce/JMH-13-247-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d609/10025816/0a5a28130e0b/JMH-13-247-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d609/10025816/22e3f27b1b77/JMH-13-247-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d609/10025816/c0ef8f4f8a34/JMH-13-247-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d609/10025816/3a2db438c9ce/JMH-13-247-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d609/10025816/0a5a28130e0b/JMH-13-247-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d609/10025816/22e3f27b1b77/JMH-13-247-g004.jpg

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本文引用的文献

1
Quantification of Leydig cells and stromal hyperplasia in the postmenopausal ovary of women with endometrial carcinoma.绝经后子宫内膜癌患者卵巢间质中 Leydig 细胞和间质增生的定量分析。
Hum Pathol. 2019 Mar;85:119-127. doi: 10.1016/j.humpath.2018.10.022. Epub 2018 Nov 11.
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Cell Origins of High-Grade Serous Ovarian Cancer.高级别浆液性卵巢癌的细胞起源
Cancers (Basel). 2018 Nov 12;10(11):433. doi: 10.3390/cancers10110433.
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Primary Fallopian Tube Carcinoma: A Case Report and Literature Review.原发性输卵管癌：一例病例报告及文献综述
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Postchemotherapy histopathological evaluation of ovarian carcinoma: a 40-case study.卵巢癌化疗后组织病理学评估：一项40例病例研究
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Morphological effects of chemotherapy on ovarian carcinoma.化疗对卵巢癌的形态学影响。
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