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病例报告:A型急性主动脉夹层合并脑灌注不良的多部位灌注策略

Case report: Multi-site perfusion strategy for type A acute aortic dissection complicated with cerebral malperfusion.

作者信息

Besa Santiago, Castelli Fiorenza, Garrido-Olivares Luis, González Rodrigo, Marine Leopoldo, Becker Pedro

机构信息

Division of Surgery, Department of Cardiovascular Surgery, Pontificia Universidad Católica de Chile, Santiago, Chile.

Medical School, Pontificia Universidad Católica de Chile, Santiago, Chile.

出版信息

Front Cardiovasc Med. 2023 Mar 6;10:1124181. doi: 10.3389/fcvm.2023.1124181. eCollection 2023.

DOI:10.3389/fcvm.2023.1124181
PMID:36950285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10025532/
Abstract

Acute type A dissection presenting with cerebral malperfusion has high morbidity and mortality. Given the complexity of underlying vascular involvement, it is a challenging clinical scenario. Many of these patients are not deemed surgical candidates. If surgery is considered, it often requires complex aortic arch and neck vessel reconstruction. We present a 48-year-old male with an acute type A aortic dissection that presented with paraplegia and decreased level of consciousness. A Computed Tomography showed occlusion of both common carotid arteries. He was successfully treated with a multi-site perfusion strategy and a Hybrid Frozen Elephant Trunk graft to achieve fast restoration of the cerebral circulation and minimize brain ischemia and permanent neurological damage. From this case, we learn that aggressive arch and neck vessel reconstruction supported by multi-site perfusion could help improve mortality and neurological outcomes in selected patients.

摘要

表现为脑灌注不良的急性A型主动脉夹层具有很高的发病率和死亡率。鉴于潜在血管受累的复杂性,这是一个具有挑战性的临床情况。这些患者中的许多人不被认为是手术候选人。如果考虑手术,通常需要复杂的主动脉弓和颈部血管重建。我们报告一名48岁男性,患有急性A型主动脉夹层,表现为截瘫和意识水平下降。计算机断层扫描显示双侧颈总动脉闭塞。他通过多部位灌注策略和杂交冷冻象鼻移植物成功治疗,以实现脑循环的快速恢复,并最大限度地减少脑缺血和永久性神经损伤。从这个病例中,我们了解到在多部位灌注支持下积极进行主动脉弓和颈部血管重建有助于改善部分患者的死亡率和神经功能结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5c0/10025532/c6cd8a81c1d2/fcvm-10-1124181-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5c0/10025532/a42509c58591/fcvm-10-1124181-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5c0/10025532/c6cd8a81c1d2/fcvm-10-1124181-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5c0/10025532/a42509c58591/fcvm-10-1124181-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5c0/10025532/c6cd8a81c1d2/fcvm-10-1124181-g0002.jpg

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引用本文的文献

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Cureus. 2023 Oct 10;15(10):e46821. doi: 10.7759/cureus.46821. eCollection 2023 Oct.

本文引用的文献

1
The frozen elephant trunk technique: impact of proximalization and the four-sites perfusion technique.冷冻象鼻技术:近端化和四点灌注技术的影响。
Eur J Cardiothorac Surg. 2021 Dec 27;61(1):195-203. doi: 10.1093/ejcts/ezab295.
2
Prediction of mortality rate in acute type A dissection: the German Registry for Acute Type A Aortic Dissection score.急性A型主动脉夹层死亡率预测:德国急性A型主动脉夹层注册研究评分
Eur J Cardiothorac Surg. 2020 Oct 1;58(4):700-706. doi: 10.1093/ejcts/ezaa156.
3
Surgery for type A aortic dissection in patients with cerebral malperfusion: Results from the International Registry of Acute Aortic Dissection.
急性A型主动脉夹层脑灌注不良患者的外科治疗:国际急性主动脉夹层注册研究结果。
J Thorac Cardiovasc Surg. 2021 May;161(5):1713-1720.e1. doi: 10.1016/j.jtcvs.2019.11.003. Epub 2019 Nov 15.
4
Type A aortic dissection complicated by malperfusion syndrome.A型主动脉夹层合并灌注不良综合征。
Curr Opin Cardiol. 2019 Nov;34(6):610-615. doi: 10.1097/HCO.0000000000000667.
5
Do not leave the heart arrested. Non-cardioplegic continuous myocardial perfusion during complex aortic arch repair improves cardiac outcome.不要使心脏停搏。在复杂主动脉弓修复术中进行非停跳持续心肌灌注可改善心脏预后。
Eur J Cardiothorac Surg. 2016 Jan;49(1):141-8. doi: 10.1093/ejcts/ezv009. Epub 2015 Feb 10.
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Operative techniques in patients with type A dissection complicated by cerebral malperfusion.A型主动脉夹层合并脑灌注不良患者的手术技术
Eur J Cardiothorac Surg. 2014 Aug;46(2):156-66. doi: 10.1093/ejcts/ezu251.
7
Patients with type A acute aortic dissection presenting with major brain injury: should we operate on them?急性 A 型主动脉夹层合并严重脑损伤患者:我们应该对其进行手术治疗吗?
J Thorac Cardiovasc Surg. 2013 Mar;145(3 Suppl):S213-21.e1. doi: 10.1016/j.jtcvs.2012.11.054.
8
Mortality in acute type A aortic dissection: validation of the Penn classification.急性 A 型主动脉夹层的死亡率:彭分类法的验证。
Ann Thorac Surg. 2011 Oct;92(4):1376-82. doi: 10.1016/j.athoracsur.2011.05.011. Epub 2011 Aug 19.
9
Carotid artery cannulation in aortic surgery.主动脉手术中的颈动脉插管
J Thorac Cardiovasc Surg. 2006 Dec;132(6):1398-403. doi: 10.1016/j.jtcvs.2006.07.024. Epub 2006 Nov 20.