Data evaluating triamcinolone acetonide and triamcinolone hexacetonide loaded poly(δ-valerolactone--allyl-δ-valerolactone) microparticles.

Advanced drug delivery strategies can be used to enhance the therapeutic effectiveness of locally delivered corticosteroids. Poly(δ-valerolactone--allyl-δ-valerolactone) microparticles (PVL--PAVL MPs) were evaluated for delivery of two corticosteroids, triamcinolone acetonide and triamcinolone hexacetonide. PVL--PAVL MPs were prepared using a modified oil-in-water emulsification method, followed by a UV-initiated cross-linking process. The resulting PVL--PAVL MPs were purified with an excess amount of water and then acetone to remove residual surfactant, cross-linker, and catalyst before lyophilization. Triamcinolone acetonide and triamcinolone hexacetonide were independently loaded into the resulting PVL--PAVL MPs via a post-loading swelling-equilibrium method. The drug-loaded MPs were characterized in terms of drug loading (determined by high-performance liquid chromatography, HPLC), thermal properties (determined by differential scanning calorimetry, DSC), and drug release kinetics (with quantification of drug using HPLC) to better understand the suitability of PVL--PAVL MPs for delivery of corticosteroids. These data demonstrate the potential of PVL--PAVL MPs as a promising drug delivery platform for the sustained release of corticosteroids. Raw data have been made available on Mendeley Data. Additional details on PVL--PAVL MPs were previously reported [1].