Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Front Endocrinol (Lausanne). 2023 Mar 6;14:1093991. doi: 10.3389/fendo.2023.1093991. eCollection 2023.
Insulin resistance (IR) is a normal feature of pregnancy and plays a crucial role in the pathophysiology of hypertensive disorder of pregnancy (HDP). The triglyceride-glucose index (TyG index) has been shown as a simple and reliable alternative IR marker. This work aimed to investigate the association between the TyG index and the incidence of HDP and adverse pregnancy outcomes.
From January 2016 to December 2018, 289 women with HDP and 861 women without HDP were recruited at Shanghai Fifth People's Hospital, Fudan University to determine the relationship between the TyG index and the incidence of HDP and adverse pregnancy outcomes.
In the case-control study, the incidence of HDP was found to be significantly associated with the TyG index. Moreover, logistic regression indicated that the TyG index is an independent risk factor for HDP development and incidence of low birth weight (LBW) and fetal distress. In the cohort study, the results showed that the TyG index increased, there was a stepwise increase in HDP incidence, SBP, and DBP levels one week before delivery as well as in LBW and fetal distress incidence. The early trimester TyG index was positively associated with pre-pregnancy BMI, systolic blood pressure (SBP), and diastolic blood pressure (DBP) one week before delivery. Spline regression showed that there was a significant linear association between HDP incidence and early trimester TyG index when it was >8.5.
This work suggested that the early trimester TyG index was closely associated with the development of HDP and adverse pregnancy outcomes.
胰岛素抵抗（IR）是妊娠的正常特征，在妊娠高血压疾病（HDP）的病理生理学中起着至关重要的作用。甘油三酯-葡萄糖指数（TyG 指数）已被证明是一种简单可靠的替代 IR 标志物。本研究旨在探讨 TyG 指数与 HDP 发生率及不良妊娠结局的关系。
本研究于 2016 年 1 月至 2018 年 12 月在复旦大学附属上海市第五人民医院招募了 289 例 HDP 患者和 861 例非 HDP 患者，以确定 TyG 指数与 HDP 发生率及不良妊娠结局的关系。
在病例对照研究中，发现 HDP 的发生率与 TyG 指数显著相关。此外，logistic 回归分析表明，TyG 指数是 HDP 发展和低出生体重（LBW）及胎儿窘迫发生率的独立危险因素。在队列研究中，结果表明 TyG 指数增加，HDP 发生率、分娩前一周 SBP 和 DBP 水平以及 LBW 和胎儿窘迫发生率呈逐步增加趋势。早孕期 TyG 指数与妊娠前 BMI、分娩前一周 SBP 和 DBP 呈正相关。样条回归显示，早孕期 TyG 指数>8.5 时，HDP 发生率与 TyG 指数之间存在显著线性关系。
本研究表明，早孕期 TyG 指数与 HDP 的发生及不良妊娠结局密切相关。
