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The common variant N372H in BRCA2 gene may be associated with idiopathic male infertility with azoospermia or severe oligozoospermia.BRCA2基因中的常见变异N372H可能与特发性无精子症或严重少精子症的男性不育有关。
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本文引用的文献

1
Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries.精子数量的时间趋势：对 20 世纪和 21 世纪全球采集样本的系统回顾和荟萃回归分析。
Hum Reprod Update. 2023 Mar 1;29(2):157-176. doi: 10.1093/humupd/dmac035.
2
Temporal decline of sperm concentration: role of endocrine disruptors.精子浓度的时间性下降：内分泌干扰物的作用
Endocrine. 2023 Jan;79(1):1-16. doi: 10.1007/s12020-022-03136-2. Epub 2022 Oct 4.
3
Analysis of 29 Targeted Genes for Non-Obstructive Azoospermia: The Relationship between Genetic Testing and Testicular Histology.非梗阻性无精子症29个靶向基因分析：基因检测与睾丸组织学的关系
World J Mens Health. 2023 Apr;41(2):422-433. doi: 10.5534/wjmh.220009. Epub 2022 Jul 14.
4
Effect of varicocelectomy on sperm deoxyribonucleic acid fragmentation rates in infertile men with clinical varicocele: a systematic review and meta-analysis.临床精索静脉曲张男性不育患者精索静脉结扎术对精子脱氧核糖核酸碎片化率的影响：系统评价和荟萃分析。
Fertil Steril. 2021 Sep;116(3):696-712. doi: 10.1016/j.fertnstert.2021.04.003. Epub 2021 May 10.
5
Disorders of spermatogenesis: Perspectives for novel genetic diagnostics after 20 years of unchanged routine.精子发生障碍：常规诊断20年未变后的新型基因诊断前景
Med Genet. 2018;30(1):12-20. doi: 10.1007/s11825-018-0181-7. Epub 2018 Feb 26.
6
Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts.男性不育的原因：一项针对1737例精子总数减少患者的9年前瞻性单中心研究。
Hum Reprod. 2017 Jan;32(1):18-31. doi: 10.1093/humrep/dew284. Epub 2016 Nov 17.
7
Definition and epidemiology of unexplained infertility.不明原因不孕症的定义与流行病学
Obstet Gynecol Surv. 2014 Feb;69(2):109-15. doi: 10.1097/OGX.0000000000000043.
8
National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys.1990 年以来全球、区域和国家不孕症患病率的趋势：对 277 项健康调查的系统分析。
PLoS Med. 2012;9(12):e1001356. doi: 10.1371/journal.pmed.1001356. Epub 2012 Dec 18.

Editorial: Male idiopathic infertility: Novel possible targets, volume II.

作者信息

Cannarella Rossella, Jezek Davor, Condorelli Rosita A, Calogero Aldo E

机构信息

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.

出版信息

Front Endocrinol (Lausanne). 2023 Mar 6;14:1172878. doi: 10.3389/fendo.2023.1172878. eCollection 2023.

DOI:10.3389/fendo.2023.1172878
PMID:36950697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10026698/
Abstract
摘要