Rabinovich P D, Guzachev A A
Kardiologiia. 1987 Oct;27(10):44-8.
Capacity for the excretion of cholesterol (CS) and bile acids was studied, using an original cholesterol load test, in atherosclerotic patients. They showed reduced fecal excretion of neutral sterols and bile acids following cholesterol load, unlike normal subjects, whose respective values were increased irrespective of age. Fecal excretion of these substances was particularly low in second-type hyperlipoproteinemia. Atherosclerosis-related changes of sterol balance may be an evidence of latent incompetence of mechanisms of hepatic evacuation of substances that may be regarded as atherosclerotic risk factors.
利用一项原创的胆固醇负荷试验,对动脉粥样硬化患者排泄胆固醇(CS)和胆汁酸的能力进行了研究。与正常受试者不同,正常受试者无论年龄大小,其相应值都会升高,而这些患者在胆固醇负荷后粪便中中性固醇和胆汁酸的排泄减少。在Ⅱ型高脂蛋白血症患者中,这些物质的粪便排泄量特别低。与动脉粥样硬化相关的固醇平衡变化可能表明肝脏清除那些可被视为动脉粥样硬化危险因素的物质的机制存在潜在功能不全。