Department of Radiation Oncology, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, Zhejiang, China.
Department of Medical Oncology, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, Zhejiang, China.
Immunotherapy. 2023 Apr;15(6):409-416. doi: 10.2217/imt-2022-0265. Epub 2023 Mar 23.
Because of their efficacy in improving prognosis, immune checkpoint inhibitors (ICIs) are widely used in patients with non-small-cell lung cancer. However, approximately half of patients experience immune-related adverse events, including autoimmune encephalitis, during treatment. Herein the authors present a case of ICI-associated autoimmune encephalitis, resulted in a favorable prognosis after treatment with intravenous immunoglobulin and methylprednisolone. The authors also review the literature regarding ICI-associated autoimmune encephalitis and summarize the clinical features, treatment strategies and prognostic outcomes in patients with non-small-cell lung cancer. The present case suggested that early detection of autoimmune encephalitis might be significant for the management of severe adverse events in patients exposed to ICIs.
由于免疫检查点抑制剂（ICIs）在改善非小细胞肺癌患者预后方面的疗效显著，因此被广泛应用。然而，约有一半的患者在治疗过程中会发生免疫相关不良反应，包括自身免疫性脑炎。在此，作者报告了一例 ICI 相关自身免疫性脑炎病例，该患者在接受静脉注射免疫球蛋白和甲基强的松龙治疗后，预后良好。作者还对与 ICI 相关的自身免疫性脑炎的文献进行了回顾，并总结了非小细胞肺癌患者的临床特征、治疗策略和预后结果。本病例提示，早期发现自身免疫性脑炎对于管理接受 ICI 治疗的患者的严重不良反应可能具有重要意义。
