Departamento de Fisiología, Instituto Universitario de Biomarcadores de Patologías Moleculares, Universidad de Extremadura, Caceres, Spain.
J Cell Physiol. 2023 Apr;238(4):714-726. doi: 10.1002/jcp.30971. Epub 2023 Mar 23.
Store operated Ca entry (SOCE) is a cornerstone for the maintenance of intracellular Ca homeostasis and the regulation of a variety of cellular functions. SOCE is mediated by STIM and Orai proteins following the activation of inositol 1,4,5-trisphosphate receptors. Then, a reduction of the endoplasmic reticulum intraluminal Ca concentration is sensed by STIM proteins, which undergo a conformational change and activate plasma membrane Ca channels comprised by Orai proteins. STIM1/Orai-mediated Ca signals are finely regulated and modulate the activity of different transcription factors, including certain isoforms of the nuclear factor of activated T-cells, the cAMP-response element binding protein, the nuclear factor κ-light chain-enhancer of activated B cells, c-fos, and c-myc. These transcription factors associate SOCE with a plethora of signaling events and cellular functions. Here we provide an overview of the current knowledge about the role of Orai channels in the regulation of transcription factors through Ca -dependent signaling pathways.
钙库操作钙内流（SOCE）是维持细胞内钙稳态和调节多种细胞功能的基石。SOCE 是由肌醇 1,4,5-三磷酸受体激活后 STIM 和 Orai 蛋白介导的。然后，内质网腔钙浓度的降低由 STIM 蛋白感知，STIM 蛋白发生构象变化并激活由 Orai 蛋白组成的质膜钙通道。STIM1/Orai 介导的 Ca 信号受到精细调节，并调节不同转录因子的活性，包括激活 T 细胞的核因子的某些同工型、cAMP 反应元件结合蛋白、激活 B 细胞的核因子 κ-轻链增强子、c-fos 和 c-myc。这些转录因子将 SOCE 与大量的信号事件和细胞功能联系起来。在这里，我们概述了 Orai 通道在通过 Ca 依赖性信号通路调节转录因子方面的作用的最新知识。
