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冷冻消融治疗转移性乳腺癌患者的远隔效应。

Abscopal Effect Following Cryoablation in a Patient with Metastatic Breast Cancer.

机构信息

Department of Surgery, Mayo Clinic, Jacksonville, FL 32224, USA.

Department of Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.

出版信息

Front Biosci (Schol Ed). 2023 Jan 16;15(1):2. doi: 10.31083/j.fbs1501002.

DOI:10.31083/j.fbs1501002
PMID:36959110
Abstract

While breast cancer is a common disease with many available treatment options, many patients still have limited responses, especially those with metastatic breast cancer. Surgery of the primary tumor or metastatic sites is often not part of the treatment regimen for patients with metastatic breast cancer. Cryoablation is a relatively non-invasive procedure that is being investigated for patients with breast cancer. Patients with metastatic breast cancer who are not surgical candidates may derive benefit from cryoablation through the abscopal effect. In this case report, we present a patient with stage IV breast cancer who was treated with cryoablation of the primary breast tumor and showed evidence of an abscopal effect in regional and distant metastases.

摘要

虽然乳腺癌是一种常见疾病,有许多治疗选择,但许多患者的反应仍然有限,尤其是转移性乳腺癌患者。手术切除原发肿瘤或转移部位通常不是转移性乳腺癌患者治疗方案的一部分。冷冻消融术是一种相对非侵入性的治疗方法,正在对乳腺癌患者进行研究。不适合手术的转移性乳腺癌患者可能通过远隔效应从冷冻消融中获益。在本病例报告中,我们介绍了一名患有 IV 期乳腺癌的患者,该患者接受了原发乳腺肿瘤的冷冻消融治疗,并在局部和远处转移灶中显示出远隔效应的证据。

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Transl Cancer Res. 2025 Feb 28;14(2):1467-1478. doi: 10.21037/tcr-24-1415. Epub 2025 Feb 26.
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Cryoablation of primary breast cancer tumors induces a systemic abscopal effect altering TIME (Tumor Immune Microenvironment) in distant tumors.原发性乳腺癌肿瘤的冷冻消融诱导全身远隔效应,改变远处肿瘤的肿瘤免疫微环境(TIME)。
Front Immunol. 2024 Dec 2;15:1498942. doi: 10.3389/fimmu.2024.1498942. eCollection 2024.
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Acad Radiol. 2024 Dec;31(12):4759-4771. doi: 10.1016/j.acra.2024.07.017. Epub 2024 Aug 5.
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Tissue Ablation: Applications and Perspectives.组织消融:应用与展望。
Adv Mater. 2024 Aug;36(32):e2310856. doi: 10.1002/adma.202310856. Epub 2024 Jun 6.
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