多囊卵巢综合征：研究的前150年

The polycystic ovary syndrome: the first 150 years of study.

作者信息

Adashi Eli Y, Cibula David, Peterson Matthew, Azziz Ricardo

机构信息

Department of Medical Science, the Warren Alpert Medical School, Brown University, Providence, Rhode Island.

Gynecologic Oncology Center, Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University and General University Hospital (Central and Eastern European Gynecologic Oncology Group, CEEGOG), Prague, Czech Republic.

出版信息

F S Rep. 2022 Dec 22;4(1):2-18. doi: 10.1016/j.xfre.2022.12.002. eCollection 2023 Mar.

DOI:10.1016/j.xfre.2022.12.002

PMID:36959968

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10028479/

Abstract

The communities of reproductive medicine and reproductive sciences have been witness to an enormous acceleration of interest in polycystic ovary syndrome (PCO) since the mid-19th century. Although progress has been increasingly palpable, the fundamentals of the etiology and pathophysiology of PCO remain as elusive as ever. Particularly lacking is a requisite understanding of events at the cellular and molecular levels. As we cross the millennial divide, it appears appropriate that an interim progress report be crafted. This treatise is attempting to meet this objective. What follows traces the chronology of the recorded history of PCO in 4 parts.

摘要

自19世纪中叶以来，生殖医学和生殖科学领域对多囊卵巢综合征（PCO）的关注急剧加速。尽管进展越来越明显，但PCO的病因和病理生理学的基本原理仍然一如既往地难以捉摸。尤其缺乏的是对细胞和分子水平事件的必要理解。在我们跨越千禧年之际，撰写一份中期进展报告似乎是合适的。本论文试图实现这一目标。以下内容分四个部分追溯了PCO有记录历史的年表。