川崎病中高水平含IgA的循环免疫复合物及分泌型IgA
High levels of IgA-containing circulating immune complex and secretory IgA in Kawasaki disease.
作者信息
Ohshio G, Furukawa F, Khine M, Yoshioka H, Kudo H, Hamashima Y
机构信息
Department of Pathology, Faculty of Medicine, Kyoto University.
出版信息
Microbiol Immunol. 1987;31(9):891-8. doi: 10.1111/j.1348-0421.1987.tb03150.x.
Sera of patients with Kawasaki disease were studied for the levels of IgA-containing (C3-fixing) circulating immune complexes (IgA-CIC), IgG-containing (IgG-)CIC, total IgA, secretory IgA, and complement component (C3) by means of enzyme-linked immunosorbent assays or single radial immunodiffusion methods. There was significantly high level of IgA-CIC, but not IgG-CIC. The levels of total IgA, secretory IgA, and C3 were significantly elevated. Significantly high levels of secretory IgA were found in 22 (51%) of 43 patients. The proportion of secretory IgA to total IgA also increased. These abnormalities in the IgA system may play a role in Kawasaki disease.
采用酶联免疫吸附测定法或单向免疫扩散法，对川崎病患者血清中的含IgA（补体C3结合型）循环免疫复合物（IgA-CIC）、含IgG循环免疫复合物（IgG-CIC）、总IgA、分泌型IgA及补体成分（C3）水平进行了研究。结果发现，IgA-CIC水平显著升高，而IgG-CIC水平无明显变化。总IgA、分泌型IgA及C3水平均显著升高。43例患者中有22例（51%）的分泌型IgA水平显著升高。分泌型IgA占总IgA的比例也有所增加。IgA系统的这些异常可能在川崎病中发挥作用。
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