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妊娠期慢性高血压:心血管疾病风险与预防的新视角。

Chronic Hypertension in Pregnancy: A Lens Into Cardiovascular Disease Risk and Prevention.

机构信息

Department of Medicine, Division of General Internal Medicine (N.A.C.), Northwestern University Feinberg School of Medicine.

Department of Medicine, Division of Hospital Medicine (I.K.E.), Northwestern University Feinberg School of Medicine.

出版信息

Hypertension. 2023 Jun;80(6):1162-1170. doi: 10.1161/HYPERTENSIONAHA.122.19317. Epub 2023 Mar 24.

Abstract

Hypertension is a major, modifiable risk factor for cardiovascular disease (CVD) in the United States. Over the past decade, the prevalence of chronic hypertension (CHTN) during pregnancy has nearly doubled with persistent race- and place-based disparities. Blood pressure elevations are of particular concern during pregnancy given higher risk of maternal and fetal morbidity and mortality, as well as higher lifetime risk of CVD in birthing individuals with CHTN. When identified during pregnancy, CHTN can, therefore, serve as a lens into CVD risk, as well as a modifiable target to mitigate cardiovascular risk throughout the life course. Health services and public health interventions that equitably promote cardiovascular health during the peripartum period could have an important impact on preventing CHTN and reducing lifetime risk of CVD. This review will summarize the epidemiology and guidelines for the diagnosis and management of CHTN in pregnancy; describe the current evidence for associations between CHTN, adverse pregnancy outcomes, and CVD; and identify opportunities for peripartum care to equitably reduce hypertension and CVD risk throughout the life course.

摘要

高血压是美国心血管疾病(CVD)的一个主要可改变的危险因素。在过去的十年中,慢性高血压(CHTN)在怀孕期间的患病率几乎翻了一番,而且存在持续的种族和地域差异。鉴于孕产妇和胎儿发病率和死亡率的风险较高,以及患有 CHTN 的分娩个体一生中 CVD 的风险更高,因此怀孕期间血压升高尤其令人关注。因此,怀孕期间发现的 CHTN 可以作为 CVD 风险的一个指标,也是在整个生命过程中减轻心血管风险的一个可改变的目标。在围产期期间公平地促进心血管健康的卫生服务和公共卫生干预措施可能对预防 CHTN 和降低 CVD 的终生风险产生重要影响。本综述将总结妊娠期 CHTN 的流行病学和诊断及管理指南;描述 CHTN 与不良妊娠结局和 CVD 之间的现有关联证据;并确定围产期护理的机会,以公平地降低整个生命过程中的高血压和 CVD 风险。

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