Ben-Shahar Yuval, Shamai Yamin Tamar, Marx Sharon, Karton-Lifshin Naama, Marciano Daniele
Department of Physical Chemistry, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 74100, Israel.
Department of Analytical Chemistry, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 741000, Israel.
ACS Sens. 2023 Apr 28;8(4):1481-1488. doi: 10.1021/acssensors.2c02491. Epub 2023 Mar 24.
Metallo-supramolecular polymers offer a highly controllable platform for sensing. Their modular characteristics obtained by the ability of varying both building blocks, the metal ion and the organic ligand, provide tunability of their optical and chemical properties. Specifically, polymers based on lanthanide ions and conjugated aromatic ligands exhibit enhanced luminescence properties that can be altered by external stimulation. Herein, using europium-based polymers, we demonstrate the ability to detect different pharmaceutical amines, including in complex biological media, based on their luminescence quenching efficiency as a result of their polymer dissociation capacity. A combination of absorption, luminescence, and NMR measurements reveals combined static and dynamic quenching mechanisms that enable selective sensing of strong basic amines with high p values.
金属超分子聚合物为传感提供了一个高度可控的平台。通过改变金属离子和有机配体这两种构建单元的能力所获得的模块化特性，使其光学和化学性质具有可调性。具体而言，基于镧系离子和共轭芳香配体的聚合物表现出增强的发光特性，可通过外部刺激进行改变。在此，我们使用基于铕的聚合物，基于其聚合物解离能力导致的发光猝灭效率，证明了检测不同药物胺类的能力，包括在复杂生物介质中。吸收、发光和核磁共振测量的结合揭示了静态和动态猝灭机制的组合，能够选择性地传感具有高p值的强碱性胺类。
