Kubisz P, Parízek M, Touhami H, Brahimi S
Division of Clinical Biochemistry and Hematology, General Hospital, Cadca, Czechoslovakia.
Neoplasma. 1987;34(5):609-14.
The effect of lomustin on platelet functions was investigated in vitro using a wide battery of tests. Lomustin was found to act as a specific inhibitor of platelet aggregation, release reaction and clot retraction and to induce acquired thrombocytopathy. Thus, impairment of platelet functions might play a role in hemorrhagic complications accompanying lomustin therapy in some cases.
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