Storch B, Wildemann B, von Kummer R
Neurologische Klinik, Universität Heidelberg.
Nervenarzt. 1987 Nov;58(11):665-9.
CSF and serum from 700 patients were analysed by isoelectric focusing (IEF). Oligoclonal bands in the high alkaline range were detected in 156 cases. Ninety-five patients were diagnosed as having multiple sclerosis (MS), 38 various CNS inflammatory disorders, 18 vascular, neoplastic or degenerative and 5 patients other neurological diseases. IEF was positive in 98% of clinically definite and 85% of clinically probable MS cases and was found to be more sensitive as compared to intrathecal IgG production and evoked potentials. Neither the presence of oligoclonal IgG nor the banding distribution pattern is specific for any disease. Further characterization may be obtained by immunofixation if the antigen is known.
对700例患者的脑脊液和血清进行了等电聚焦（IEF）分析。在156例中检测到高碱性范围内的寡克隆带。95例患者被诊断为患有多发性硬化症（MS），38例患有各种中枢神经系统炎症性疾病，18例患有血管性、肿瘤性或退行性疾病，5例患有其他神经系统疾病。在临床确诊的MS病例中，IEF阳性率为98%，临床疑似病例中为85%，并且发现与鞘内IgG产生和诱发电位相比，IEF更敏感。寡克隆IgG的存在和条带分布模式都不是任何疾病所特有的。如果已知抗原，可通过免疫固定进行进一步鉴定。
