Morales María Francisca, Girard Lisa-Christine, Raouna Aigli, MacBeth Angus
Department of Clinical Psychology, School of Health in Social Science, The University of Edinburgh, Edinburgh, United Kingdom.
PLOS Glob Public Health. 2023 Feb 27;3(2):e0001649. doi: 10.1371/journal.pgph.0001649. eCollection 2023.
Maternal depression from the perinatal period onwards is a global health priority associated with an increased likelihood of suboptimal socio-developmental outcomes in offspring. An important aspect of this association is the extent to which sustained maternal depression impacts on these outcomes. The current review synthesised the evidence on maternal depression from the perinatal period onwards and offspring internalising, externalising, and social competence outcomes. We also identified sources of methodological bias. A systematic review following PRISMA guidelines was conducted. Longitudinal studies targeting biological mothers with depressive symptomology, detailing onset, using repeated validated measures, and assessing children's outcomes between three and 12 years were included. Twenty-four studies met inclusion criteria. Findings supported the validity of different presentations of maternal depression, including consistent identification of a group of chronically depressed mothers across countries. Mothers within this group reported poorer internalising, externalising, and social competence outcomes for their offspring, with the highest levels of child problems associated with greater maternal chronicity and symptom severity. Results differed by measurement type with mothers rating poorer outcomes in comparison to teachers reports. For timing of depression, evidence was inconsistent for independent effects of antenatal or postnatal depression on child outcomes. There was substantial variability in study quality assessment. Assessing different presentations of maternal depression is essential for capturing the longitudinal associations between maternal depression and offspring outcomes to inform targets of early intervention. Chronicity, severity, and concurrent maternal depression have important implications for children's development and should be targeted in future programme planning. Further research in low- and middle-income countries is warranted.
从围产期开始的母亲抑郁是一个全球卫生重点问题,与后代社会发育结果欠佳的可能性增加相关。这种关联的一个重要方面是母亲持续抑郁对这些结果的影响程度。本综述综合了围产期及之后母亲抑郁以及后代内化、外化和社会能力结果方面的证据。我们还确定了方法学偏倚的来源。按照PRISMA指南进行了系统综述。纳入了针对有抑郁症状的亲生母亲的纵向研究,详细说明了发病情况,使用了反复验证的测量方法,并评估了3至12岁儿童的结果。24项研究符合纳入标准。研究结果支持了母亲抑郁不同表现形式的有效性,包括在不同国家一致识别出一组慢性抑郁母亲。该组母亲报告其后代的内化、外化和社会能力结果较差,儿童问题程度最高与母亲的慢性程度和症状严重程度较高相关。结果因测量类型而异,母亲评定的结果比教师报告的结果更差。对于抑郁发生时间,产前或产后抑郁对儿童结果的独立影响证据不一致。研究质量评估存在很大差异。评估母亲抑郁的不同表现形式对于了解母亲抑郁与后代结果之间的纵向关联以指导早期干预目标至关重要。慢性程度、严重程度和母亲同时存在的抑郁对儿童发育具有重要影响,应在未来的项目规划中予以关注。低收入和中等收入国家有必要开展进一步研究。