Lovett A M, Reid N M, Buckley J A, French J B, Cameron D M
Biomed Mass Spectrom. 1979 Mar;6(3):91-7. doi: 10.1002/bms.1200060302.
A new technique is reported resulting in the direct, instantaneous analyses of trace compounds in breath. The analyses were performed using a commercial atmospheric pressure chemical ionization mass spectrometer (TAGA TM2000 APCI mass spectrometer). A known flow of breath sample is introduced into the ionization region of the mass spectrometer. The study includes the measurement and monitoring in real-time, of breath ammonia during a 24 hour and a 48 hour period. The ammonia profiles indicate a personalized daily pattern associated with each subject. This method appears to be of potential value in routine detection and treatment of hyperammonemia patients. Results also show that it is possible to obtain instantaneous analyses of several naturally occurring metabolites and other substances on breath in the ppm to ppt range, suggesting a number of diagnostic research applications.
据报道，一种新技术可对呼出气体中的痕量化合物进行直接、即时分析。分析使用的是商用大气压化学电离质谱仪（TAGA TM2000 APCI质谱仪）。将已知流量的呼气样本引入质谱仪的电离区域。该研究包括在24小时和48小时内对呼气氨进行实时测量和监测。氨谱显示了与每个受试者相关的个性化日常模式。这种方法在高氨血症患者的常规检测和治疗中似乎具有潜在价值。结果还表明，有可能对呼出气体中ppm至ppt范围内的几种天然代谢物和其他物质进行即时分析，这暗示了许多诊断研究应用。
