Hotta O, Yoshizawa N, Oshima S, Takeuchi A, Kawamura O, Kondo S, Kubota T, Niwa H
Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Nephron. 1987;47(4):262-5. doi: 10.1159/000184521.
The relationship between glomerular sclerosis and hyaline arteriolosclerosis (HA) or tubulo-interstitial (T-I) change was investigated in 66 patients with IgA glomerulonephropathy (IgA-GN) and in 12 patients with idiopathic focal segmental glomerulosclerosis (FGS). More than a 10% incidence of global sclerosis was noted in 15 patients with IgA-GN and in 9 patients with FGS. There was no significant discrepancy of age between patients with IgA-GN and those with FGS (IgA-GN: 37.5 +/- 12.5; FGS: 35.7 +/- 10.3). In patients with IgA-GN, 7 out of 15 were HA-positive (46.7%), whereas in patients with FGS, 7 out of 9 were HA-positive (77.8%). However, a close correlation was observed between glomerular sclerosis and T-I change only in patients with IgA-GN (r = 0.82; p less than 0.001). The results suggested that in the case of IgA-GN, T-I change was related to the prognosis of glomerular sclerosis. In addition, it is assumed that a possible correlation exists between FGS and HA.
在66例IgA肾病（IgA-GN）患者和12例特发性局灶节段性肾小球硬化症（FGS）患者中，研究了肾小球硬化与玻璃样小动脉硬化（HA）或肾小管间质（T-I）改变之间的关系。15例IgA-GN患者和9例FGS患者中，全球硬化发生率超过10%。IgA-GN患者与FGS患者之间的年龄无显著差异（IgA-GN：37.5±12.5；FGS：35.7±10.3）。在IgA-GN患者中，15例中有7例HA阳性（46.7%），而在FGS患者中，9例中有7例HA阳性（77.8%）。然而，仅在IgA-GN患者中观察到肾小球硬化与T-I改变之间存在密切相关性（r = 0.82；p＜0.001）。结果表明，在IgA-GN病例中，T-I改变与肾小球硬化的预后相关。此外，推测FGS与HA之间可能存在相关性。
