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童年期虐待对重度抑郁症患者特质性抑郁的影响:反刍思维与正念注意觉知的有调节的中介模型

The influence of childhood maltreatment on trait depression in patients with major depressive disorder: A moderated mediation model of rumination and mindful attention awareness.

作者信息

Mao Lingyun, Wu Yunhong, Hong Xin, Li Pan, Yuan Xin, Hu Maorong

机构信息

Department of Psychosomatic Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Department of Psychosomatic Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China.

出版信息

J Affect Disord. 2023 Jun 15;331:130-138. doi: 10.1016/j.jad.2023.03.052. Epub 2023 Mar 22.

Abstract

Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders. Individuals who were exposed to childhood maltreatment might be an especially vulnerable group and were more likely to meet the diagnostic criteria for depression than those who were not. Trait depression refers to a personality trait predisposition to depression, expressed as the frequency of symptoms rather than a transient depressive mood state. Clarifying the relationship between childhood maltreatment and trait depression in patients with MDD has therefore become an important field of research. Childhood Trauma Questionnaire-Short Form (CTQ-SF), Ruminative Responses Scale (RRS), State-Trait Depression Scale (ST-DEP), and Mindful Attention Awareness Scale (MAAS) were used as research instruments. SPSS 23.0 statistical software was used for statistical analysis and examined the moderated mediation models. A total of 288 patients with MDD were included in this study. After standardization of the variables, the model revealed childhood maltreatment was positively associated with trait depression (β = 0.215, p < 0.001) and that rumination partially mediated the effect between childhood trauma and trait depression. Mindfulness moderated the association between rumination and trait depression in depressed patients (β = 0.171, p < 0.001). Simple slope tests showed that rumination significantly predicted trait depression in patients with high levels of mindfulness (bsimple = 0.460, p < 0.001, 95%CI = [0.339, 0.581]), while this predictive effect was not significant in patients with low levels (bsimple = 0.119, p = 0.097, 95%CI = [-0.022, 0.261]). After adding mediating variables, we found that the negative impact of childhood maltreatment on trait depression was both directly and indirectly through the patients' own ruminative levels. However, mindfulness performed a critical moderating role in the overall mediating model, aggravating the negative impact of childhood maltreatment on trait depression. There are several limitations in this study: the history of childhood maltreatment was reviewed and reported; the MAAS was a single-dimensional questionnaire that fails to measure the content of other mindfulness factors; cross-sectional data could not be used to infer the causal relationship between variables.

摘要

重度抑郁症(MDD)是最常见的精神疾病之一。童年期遭受过虐待的个体可能是一个特别脆弱的群体,比未遭受过虐待的个体更有可能符合抑郁症的诊断标准。特质性抑郁是指一种易患抑郁症的人格特质,表现为症状出现的频率,而非短暂的抑郁情绪状态。因此,阐明MDD患者童年期虐待与特质性抑郁之间的关系已成为一个重要的研究领域。研究采用儿童期创伤问卷简表(CTQ-SF)、沉思反应量表(RRS)、状态-特质抑郁量表(ST-DEP)和正念注意觉知量表(MAAS)作为研究工具。使用SPSS 23.0统计软件进行统计分析并检验中介调节模型。本研究共纳入288例MDD患者。对变量进行标准化后,模型显示童年期虐待与特质性抑郁呈正相关(β = 0.215,p < 0.001),沉思在童年期创伤与特质性抑郁之间的效应中起部分中介作用。正念调节了抑郁症患者沉思与特质性抑郁之间的关联(β = 0.171,p < 0.001)。简单斜率检验表明,在高正念水平的患者中,沉思能显著预测特质性抑郁(bsimple = 0.460,p < 0.001,95%CI = [0.339, 0.581]),而在低正念水平的患者中,这种预测作用不显著(bsimple = 0.119,p = 0.097,95%CI = [-0.022, 0.261])。加入中介变量后,我们发现童年期虐待对特质性抑郁的负面影响既直接又间接通过患者自身的沉思水平起作用。然而,正念在整个中介模型中起关键的调节作用,加剧了童年期虐待对特质性抑郁的负面影响。本研究存在若干局限性:童年期虐待史通过回顾和报告获取;MAAS是一个单维度问卷,未能测量其他正念因素的内容;横断面数据无法用于推断变量之间的因果关系。

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