Wang Chunru, Lu Qingyang, Xiang Yingjie, Yin Yulan, Li Junyao, Liu Yalu, Wu Xiaochen
Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Department of Ophthalmology, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Daxue Road 269, Xuzhou 221002, China; Xuzhou First People's Hospital, Daxue Road 269, Xuzhou 221002, China.
Int J Biol Macromol. 2023 May 31;238:124133. doi: 10.1016/j.ijbiomac.2023.124133. Epub 2023 Mar 23.
Caffeic acid (CA) is an antioxidant phenolic compound that enriched in coffee beans, however, its administration often restrains by the instability and low solubility. Nanoparticle encapsulation is an effective approach to improve the therapeutic activity of CA. For example, silk sericin (SS), a natural biomaterial finds applications in food, cosmetics and biomedical fields, is proved here to be an appropriate encapsulation agent for CA, and a SS/CA composite nanoparticle has been fabricated. To further improve the biocompatibility of SS/CA, a red blood cell membranes (RM) cloaking strategy is adopted. The as-formed SS/CA/RM preserves the antioxidant activity of CA, and shows satisfactory biocompatibility especially under high concentration. Hope this can provide a potential appropriative strategy to adjust the chemical stability of insoluble drugs and to improve their biocompatibility.
咖啡酸（CA）是一种富含于咖啡豆中的抗氧化酚类化合物，然而，其应用常常受到不稳定性和低溶解度的限制。纳米颗粒包封是提高CA治疗活性的有效方法。例如，丝胶蛋白（SS）作为一种天然生物材料，在食品、化妆品和生物医学领域有应用，在此被证明是CA的合适包封剂，并且已经制备出了SS/CA复合纳米颗粒。为了进一步提高SS/CA的生物相容性，采用了红细胞膜（RM）包覆策略。所形成的SS/CA/RM保留了CA的抗氧化活性，并且表现出令人满意的生物相容性，尤其是在高浓度下。希望这能提供一种潜在的合适策略来调节不溶性药物的化学稳定性并提高其生物相容性。
