Park Jin Myung, Park Namyoung, Lee Sang Hyub, Han Kyung Do, Kang Chang Don, Lee Jae Min, Paik Woo Hyun, Ryu Ji Kon, Kim Yong-Tae
Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, South Korea.
Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Seoul, South Korea.
Pancreatology. 2023 Apr;23(3):321-329. doi: 10.1016/j.pan.2023.03.004. Epub 2023 Mar 17.
/objectives: Acute pancreatitis (AP) is an acute inflammatory disorder that can occur in all age groups. The risk of AP has been shown to increase with age. However, no study has compared risk factors for AP according to age group yet. Thus, the aim of this study was to perform such comparison.
Clinical data from individuals 20 years of age and older who received a health examination arranged by the Korean national health insurance program in 2009 (n = 4,238,822) were used. First-attack AP was identified using claims data from baseline to December 2018. Incidence and risk factors of AP were analyzed for young (20-39 years old), middle-aged (40-64 years old), and old (over 65 years old) groups.
Incidences of AP in young, middle-aged, and old groups were 16.30, 27.85, and 57.19 per 100,000 person-years, respectively. Smoking, alcohol drinking, diabetes, gallstone, and chronic pancreatitis were associated with increased risk of AP in all age groups. Meanwhile, male, older age, and higher waist circumference were associated with increased risk of AP in middle-aged and old groups. In young and middle-aged groups, risk of AP was increased in the presence of hypertension and dyslipidemia. However, high income was associated with decreased risk of AP in these groups.
In this population-based cohort study, incidences and risk factors for AP differed according to age group. Thus, a tailored strategy might be needed to prevent AP according to age group.
/目的：急性胰腺炎（AP）是一种可发生于所有年龄组的急性炎症性疾病。已表明AP的风险随年龄增长而增加。然而，尚无研究按年龄组比较AP的危险因素。因此，本研究的目的是进行此类比较。
使用了2009年接受韩国国民健康保险计划安排的健康检查的20岁及以上个体的临床数据（n = 4,238,822）。利用从基线到2018年12月的理赔数据确定首次发作的AP。分析了青年组（20 - 39岁）、中年组（40 - 64岁）和老年组（65岁以上）AP的发病率和危险因素。
青年组、中年组和老年组AP的发病率分别为每10万人年16.30例、27.85例和57.19例。吸烟、饮酒、糖尿病、胆结石和慢性胰腺炎在所有年龄组中均与AP风险增加相关。同时，男性、较高年龄和较高腰围在中年组和老年组中与AP风险增加相关。在青年组和中年组中，存在高血压和血脂异常时AP风险增加。然而，高收入在这些组中与AP风险降低相关。
在这项基于人群的队列研究中，AP的发病率和危险因素因年龄组而异。因此，可能需要根据年龄组制定针对性的策略来预防AP。
