Sideways: road to gene-by-gene functional screening in malaria parasites.

作者信息

Chookajorn Thanat, Billker Oliver

机构信息

Laboratory for Molecular Infection Medicine Sweden, Umeå University, Umeå 90187, Sweden; Department of Molecular Biology, Umeå University, Umeå 90187, Sweden; Genomics and Evolutionary Medicine Unit (GEM), Centre of Excellence in Malaria Research, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

Laboratory for Molecular Infection Medicine Sweden, Umeå University, Umeå 90187, Sweden; Department of Molecular Biology, Umeå University, Umeå 90187, Sweden.

出版信息

Trends Parasitol. 2023 May;39(5):317-318. doi: 10.1016/j.pt.2023.03.007. Epub 2023 Mar 23.

DOI:10.1016/j.pt.2023.03.007

PMID:36964075

Abstract

Genome-wide screening in apicomplexan species has transformed our understanding of these parasitic protozoa. Kimmel et al. report a 'knock sideways' system and provide a powerful use case for its feasibility in a gene-by-gene screening in Plasmodium falciparum. Carefully deployed, a novel toolkit helps to dissect the biological uniqueness of an important parasite.

摘要