Institute of Neurology, University Hospital of Cagliari, Cagliari, Italy.
Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Neurol Sci. 2023 Aug;44(8):2781-2786. doi: 10.1007/s10072-023-06753-5. Epub 2023 Mar 24.
While amyotrophic lateral sclerosis (ALS) incidence has increased during the last decades, structured evidence on increased prevalence is lacking. After reporting a significant yearly increase of ALS incidence over a 10-year period, we checked for increased prevalence in Southern Sardinia over a quinquennium.
ALS patients (El Escorial Criteria) recruited from the study area and followed at ALS Centre, University of Cagliari, were included. Prevalence was computed for January 1, 2015 and January 1, 2019 and was calculated for the overall ALS population as well as for tracheostomized and non-tracheostomized patients.
We observed a non-significant trend for greater ALS prevalence in 2019 than in 2015 (18.31 per 100,000 vs. 15.26 per 100,000; rate ratio: 1.83, p = 0.01). By contrast, a significantly raising 2015 to 2019 ALS prevalence was observed in tracheostomized patients. No significant difference could be detected in non-tracheostomized.
We provided the highest prevalence rate to date reported in the worldwide literature, and also showed a non-significant raising ALS prevalence in the Sardinian population over a quinquennium. The trend in raising ALS prevalence was likely due to extended survival due to invasive interventions.
尽管肌萎缩侧索硬化症（ALS）的发病率在过去几十年中有所增加，但缺乏关于发病率增加的结构化证据。在报告了 10 年间 ALS 发病率显著增加后，我们检查了撒丁岛南部在五年期间的患病率是否增加。
我们纳入了在研究区域招募并在卡利亚里大学 ALS 中心接受随访的 ALS 患者（埃尔埃斯科里亚尔标准）。计算了 2015 年 1 月 1 日和 2019 年 1 月 1 日的患病率，并计算了总体 ALS 人群以及气管切开和非气管切开患者的患病率。
我们观察到 2019 年 ALS 患病率较 2015 年呈非显著上升趋势（18.31/100,000 比 15.26/100,000；发病率比：1.83，p=0.01）。相比之下，气管切开患者的 2015 年至 2019 年 ALS 患病率显著升高。在非气管切开患者中未检测到显著差异。
我们提供了迄今为止在全球文献中报告的最高患病率，并且还显示撒丁岛人群在五年期间 ALS 患病率呈非显著上升趋势。ALS 患病率上升的趋势可能归因于侵入性干预措施延长了生存时间。
