Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Student research committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC Endocr Disord. 2023 Mar 24;23(1):66. doi: 10.1186/s12902-023-01322-5.
Papillary thyroid carcinoma PTC is the most prevalent of all thyroid carcinomas. On the other hand, Hashimoto's thyroiditis (HT), as part of the spectrum of autoimmune thyroid diseases, is a major cause of thyroid hypofunction worldwide. Several studies have aimed to indicate a possible correlation between PTC and HT over the years. This study aims to investigate the correlation between HT disease and PTC tumor invasion rate.
In the present cross-sectional study, PTC patients with HT were selected among patients referred to the surgical ward of Shariati hospital from 2016 to 2019 and compared in terms of tumor invasion and central LN dissection. Also, a similar group of PTC patients without HT undergoing total thyroidectomy was selected for comparison. The tumor invasion rate was assessed based on invasion indices obtained from postoperative permanent pathology specimens. These indices included tumor type and size, number of involved LNs, lymphovascular involvement, perineural involvement, thyroid capsule involvement, multifocal or unifocal tumor, extrathyroidal proliferation, marginal status, and necrosis. Data were obtained and compared in the two groups with SPSS version 22.0 software.
Based on the postoperative pathology reports, 50 (56.2%) PTC patients with Hashimoto thyroiditis were compared against 39 PTC patients without Hashimoto thyroiditis. No significant difference was found between the two groups regarding tumor invasion factors such as multifocality, lymphovascular invasion, marginal invasion, extrathyroidal invasion, capsular invasion, and necrosis.
HT could not be mentioned as an aggravating factor of PTC invasion based on the invasion factors evaluated in pathology specimens.
甲状腺乳头状癌（PTC）是所有甲状腺癌中最常见的类型。另一方面，桥本甲状腺炎（HT）作为自身免疫性甲状腺疾病谱的一部分，是全球甲状腺功能减退症的主要原因。多年来，已有多项研究旨在指出 PTC 与 HT 之间可能存在相关性。本研究旨在调查 HT 疾病与 PTC 肿瘤侵袭率之间的相关性。
在这项横断面研究中，我们选择了 2016 年至 2019 年期间在 Shariati 医院外科病房就诊的伴有 HT 的 PTC 患者，并根据肿瘤侵袭和中央淋巴结清扫术进行了比较。此外，还选择了一组类似的无 HT 的 PTC 患者进行全甲状腺切除术作为对照组。肿瘤侵袭率是根据术后永久病理标本中获得的侵袭指数来评估的。这些指数包括肿瘤类型和大小、受累淋巴结数量、血管淋巴管侵犯、神经周围侵犯、甲状腺包膜侵犯、多灶性或单灶性肿瘤、甲状腺外增殖、边缘状态和坏死。使用 SPSS 版本 22.0 软件获得并比较了两组数据。
根据术后病理报告，我们比较了 50 例（56.2%）伴有桥本甲状腺炎的 PTC 患者和 39 例无桥本甲状腺炎的 PTC 患者。在肿瘤侵袭因素方面，如多灶性、血管淋巴管侵犯、边缘侵犯、甲状腺外侵犯、包膜侵犯和坏死，两组之间没有显著差异。
根据病理标本评估的侵袭因素，HT 不能被认为是 PTC 侵袭的加重因素。
