The Neuro- Lab, School of Basic Medical Sciences, Federal University of Technology Akure, Akure, Nigeria.
Department of Human Anatomy, School of Basic Medical Sciences, Federal University of Technology Akure, Akure, Nigeria.
Metab Brain Dis. 2023 Mar;38(3):831-837. doi: 10.1007/s11011-023-01203-9. Epub 2023 Mar 25.
Cell death is vital to various organismal developmental processes including brain development. Apoptosis, the most recognized programmed cell death, has been linked to several developmental processes and implicated in pruning cells to provide the ultimate tissue integrity. However, more recently, other forms of non-apoptotic programmed cell death have been identified, of which necroptosis is of predominant interest. Necroptosis is a regulated form of necrosis, activated under apoptotic-deficient conditions. Tumour necrosis factor (TNF) is a major activator of necroptosis, and the process is mediated by several kinases including receptor-interacting protein kinase (RIPK) and mixed lineage kinase domain-like protein (MLKL). Potential roles for necroptosis during brain development have been muted. Necroptosis has been implicated in mediating neurological disorders, and contributing to the severity of these disorders. Here we will review the literature on the role of necroptosis in neurodevelopment, summarizing its molecular mechanisms and highlighting potential implications for disorders of the developing brain.
细胞死亡对于包括大脑发育在内的各种生物体发育过程至关重要。细胞凋亡是最被认可的程序性细胞死亡，与许多发育过程有关，并涉及到细胞的修剪，以提供最终的组织完整性。然而，最近，已经确定了其他形式的非凋亡程序性细胞死亡，其中坏死性细胞凋亡是主要关注的形式。坏死性细胞凋亡是一种受调控的坏死形式，在凋亡缺陷的情况下被激活。肿瘤坏死因子 (TNF) 是坏死性细胞凋亡的主要激活剂，该过程由几种激酶介导，包括受体相互作用蛋白激酶 (RIPK) 和混合谱系激酶结构域样蛋白 (MLKL)。坏死性细胞凋亡在大脑发育过程中的潜在作用受到抑制。坏死性细胞凋亡被认为在介导神经紊乱方面发挥作用，并导致这些紊乱的严重程度增加。在这里，我们将回顾关于坏死性细胞凋亡在神经发育中的作用的文献，总结其分子机制，并强调其对发育中大脑紊乱的潜在影响。
