替尼酸、苄氟噻嗪和螺内酯的利钠、促尿酸排泄及降压特性比较。
Comparison of natriuretic, uricosuric, and antihypertensive properties of tienilic acid, bendrofluazide, and spironolactone.
作者信息
Roberts C J, Marshall A J, Heaton S, Barritt D W
出版信息
Br Med J. 1979 Jan 27;1(6158):224-6. doi: 10.1136/bmj.1.6158.224.
The antihypertensive properties of the new diuretic tienilic acid were investigated. Thirteen previously untreated hypertensive patients took part in a double-blind crossover study in which 30 days' treatment with tienilic acid 250 mg, bendrofluazide 5 mg, and spironolactone 100 mg were compared. Bendrofluazide caused the greatest natriuresis on the first treatment day and the most rapid fall in blood pressure. The ultimate antihypertensive effect of all three drugs was similar. Tienilic acid caused a noticeable reduction in serum urate concentrations and a rise in urate clearance, in contrast to the other two agents, which caused slight urate retention. Tienilic acid and bendrofluazide caused falls and spironolactone a rise in plasma potassium concentrations. No untoward effects were seen from any of the drugs. It is concluded that tienilic acid is a moderately potent diuretic that lowers plasma urate concentrations. It may be the drug of first choice for hypertensive patients who already have gout or are likely to develop it when taking thiazide diuretics.
对新型利尿剂替尼酸的降压特性进行了研究。13名未经治疗的高血压患者参与了一项双盲交叉研究，比较了服用250毫克替尼酸、5毫克苄氟噻嗪和100毫克螺内酯治疗30天的效果。苄氟噻嗪在治疗第一天引起的利钠作用最强，血压下降最快。三种药物最终的降压效果相似。与另外两种导致轻微尿酸潴留的药物相比，替尼酸可使血清尿酸浓度显著降低，尿酸清除率升高。替尼酸和苄氟噻嗪可使血浆钾浓度降低，而螺内酯则使其升高。未观察到任何一种药物有不良影响。结论是，替尼酸是一种中等强度的利尿剂，可降低血浆尿酸浓度。对于已经患有痛风或服用噻嗪类利尿剂可能会患痛风的高血压患者，它可能是首选药物。
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