Leader Geraldine, Curtin Andrea, Shprintzen Robert J, Whelan Sally, Coyne Rory, Mannion Arlene
Irish Centre for Autism and Neurodevelopmental Research, School of Psychology, National, University of Ireland, Galway, Ireland.
Irish Centre for Autism and Neurodevelopmental Research, School of Psychology, National, University of Ireland, Galway, Ireland.
Res Dev Disabil. 2023 May;136:104491. doi: 10.1016/j.ridd.2023.104491. Epub 2023 Mar 23.
22q11.21 deletion syndrome (22q11DS) is a neurodevelopmental syndrome caused by a microdeletion of genes at the 22q11.21 locus. It has a prevalence of 1:2000. This study investigated the prevalence of adaptive living skills, sleep problems, and mental health disorders in adults with 22q11DS and examined the relationship between these factors.
Parents with an adult son or daughter with 22q11DS completed the following: A bespoke Demographic Information Questionnaire, Sleep Questionnaire (SQ-SP), Psychopathology in Autism Checklist (PAC), and Activities of Daily Living (ADL) scale. Descriptive statistics, correlations, and one-way between groups analysis of variance (ANOVA) were conducted.
Mental health difficulties, sleep problems, and low levels of adaptive living skills are prevalent in adults with 22q11DS. Strong positive correlations were identified between sleep problems, depression, and anxiety subscale scores and moderate negative correlations between depression, psychosis, and activities of daily living skills.
Adults with 22q11DS need screening and treatment for mental health and sleep problems.
22q11.21缺失综合征（22q11DS）是一种由22q11.21位点基因微缺失引起的神经发育综合征。其患病率为1:2000。本研究调查了22q11DS成年患者的适应性生活技能、睡眠问题和心理健康障碍的患病率，并研究了这些因素之间的关系。
有成年子女患22q11DS的父母完成了以下问卷：定制的人口信息问卷、睡眠问卷（SQ-SP）、自闭症心理病理学检查表（PAC）和日常生活活动（ADL）量表。进行了描述性统计、相关性分析和组间单因素方差分析（ANOVA）。
心理健康问题、睡眠问题和适应性生活技能水平低下在22q11DS成年患者中普遍存在。睡眠问题、抑郁和焦虑分量表得分之间存在强正相关，抑郁、精神病和日常生活技能之间存在中度负相关。
22q11DS成年患者需要针对心理健康和睡眠问题进行筛查和治疗。
