研究细长矿物颗粒与间皮瘤风险的流行病学障碍。
Epidemiologic roadblocks in studying elongated mineral particles and mesothelioma risk.
机构信息
Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, 722 West 168th St. New York, NY, 10032, USA; Institute for Translational Epidemiology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY, 10029, USA.
Institute for Translational Epidemiology and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY, 10029, USA.
出版信息
Environ Res. 2023 Aug 1;230:115086. doi: 10.1016/j.envres.2022.115086. Epub 2023 Mar 23.
Elongated mineral particles (EMPs) are a type of both occupational and environmental exposures that have generated interest in the scientific community due to their potential health effects. Their possible association with mesothelioma represents an area of concern. We provide an overview of the current challenges around epidemiological assessments of EMP exposure and mesothelioma risk, including methodological aspects that need to be addressed when designing and analyzing a study on EMP exposure and mesothelioma. Future work is needed to investigate the relationship between EMPs and mesothelioma, focused on an improved definition of EMP exposure and accounting for other concomitant sources of carcinogen exposure.
伸长矿物颗粒（EMPs）是一种职业和环境暴露，由于其潜在的健康影响，引起了科学界的兴趣。它们与间皮瘤的可能关联是令人关注的领域。我们提供了关于 EMP 暴露和间皮瘤风险的流行病学评估的当前挑战的概述，包括在设计和分析 EMP 暴露和间皮瘤研究时需要解决的方法学方面。需要开展未来的工作来研究 EMPs 和间皮瘤之间的关系，重点是改进 EMP 暴露的定义，并考虑其他同时存在的致癌物暴露源。
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