Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Department of General Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.
Acad Radiol. 2024 Jan;31(1):9-18. doi: 10.1016/j.acra.2023.02.032. Epub 2023 Mar 23.
Although low muscle mass is associated with decreased lung function, studies exploring the relationship between muscle fat content and lung function impairment are scarce. This study aimed to evaluate the association of muscle mass and fatty infiltration with lung function in young adults with obesity.
We performed a retrospective cross-sectional study of patients aged 18-45 years with obesity who had impaired pulmonary function (case group, n = 66) and those with normal pulmonary function (control group, n = 198) by matching age, sex, body mass index (BMI), and height to assess whether muscle characteristics differed. Muscle mass and muscle fat content were assessed by MRI using a chemical shift-encoded sequence (IDEAL-IQ).
A total of 264 patients were enrolled (124 females; mean age 32.0 years). The case group had lower muscle mass than the control group (p = 0.012), and there was an association between low muscle mass and lung function impairment (odds ratio (OR), 3.74; 95% confidence interval (CI), 1.57-8.93). Furthermore, muscle fat content was significantly higher in cases compared to controls (7.4 (2.7) % vs. 6.2 (2.5) %, p = 0.001). Multiple logistic regression analysis showed that muscle fat content was associated with a higher risk of impaired lung function (OR, 2.10; 95% CI, 1.65-2.66), regardless of adiposity and muscle mass.
Both muscle fat content and muscle mass are associated with impaired lung function in young adults with obesity.
尽管肌肉量减少与肺功能下降有关，但研究肌肉脂肪含量与肺功能损害之间关系的研究很少。本研究旨在评估肥胖的年轻成年人中肌肉量和脂肪浸润与肺功能的关系。
我们对肺功能受损（病例组，n=66）和肺功能正常（对照组，n=198）的 18-45 岁肥胖患者进行了回顾性横断面研究，通过匹配年龄、性别、体重指数（BMI）和身高来评估肌肉特征是否存在差异。使用化学位移编码序列（IDEAL-IQ）通过 MRI 评估肌肉量和肌肉脂肪含量。
共纳入 264 例患者（女性 124 例；平均年龄 32.0 岁）。病例组的肌肉量低于对照组（p=0.012），并且低肌肉量与肺功能损害之间存在关联（比值比（OR），3.74；95%置信区间（CI），1.57-8.93）。此外，与对照组相比，病例组的肌肉脂肪含量明显更高（7.4（2.7）%比 6.2（2.5）%，p=0.001）。多因素逻辑回归分析显示，肌肉脂肪含量与肺功能受损的风险增加相关（OR，2.10；95%CI，1.65-2.66），与肥胖和肌肉量无关。
肥胖的年轻成年人中，肌肉脂肪含量和肌肉量均与肺功能受损相关。
