四种生物碱的非对映全合成。

Asymmetric Total Synthesis of Four Alkaloids.

机构信息

School of Pharmacy, Lanzhou University, No. 199 West Donggang Road, Lanzhou 730000, Gansu, China.

School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.

出版信息

Org Lett. 2023 Apr 7;25(13):2213-2217. doi: 10.1021/acs.orglett.3c00349. Epub 2023 Mar 26.

DOI:10.1021/acs.orglett.3c00349

PMID:36966439

Abstract

Asymmetric total syntheses of four alkaloids were accomplished, and among them, bisdehydrostemoninine A and stemoninine A were synthesized for the first time. Notably, these four alkaloids were divergently synthesized from a common tetracyclic intermediate, which was easily obtained from a known compound. Friedel-Crafts acylation was employed to introduce the key side chain at position C3 of alkaloids.

摘要

完成了四个生物碱的不对称全合成，其中双去氢石蒜宁 A 和石蒜宁 A 是首次合成的。值得注意的是，这四个生物碱是从一个共同的四环中间体中发散合成的，该中间体很容易从已知化合物中获得。傅克酰基化反应被用来在生物碱的 C3 位引入关键的侧链。