Wu Yuxuan, Jiang Huiyan, Pang Wenbo
Software College, Northeastern University, No. 195, Chuangxin Road, Hunnan District, Shenyang, 110169, Liaoning, China.
Software College, Northeastern University, No. 195, Chuangxin Road, Hunnan District, Shenyang, 110169, Liaoning, China.
Comput Biol Med. 2023 May;158:106818. doi: 10.1016/j.compbiomed.2023.106818. Epub 2023 Mar 22.
Automatic Medical segmentation of medical images is an important part in the field of computer medical diagnosis, among which tumor segmentation is an important branch of medical image segmentation. Accurate automatic segmentation method is very important in medical diagnosis and treatment. Positron emission computed tomography (PET) and X-ray computed tomography (CT) images are widely used in medical image segmentation to help doctors accurately locate information such as tumor location and shape, providing metabolic and anatomical information, respectively. At present, PET/CT images have not been effectively combined in the research of medical image segmentation, and the complementary semantic information between the superficial and deep layers of neural network has not been ensured. To solve the above problems, this paper proposed a Multi-scale Residual Attention network (MSRA-Net) for tumor segmentation of PET/CT. We first use an attention-fusion based approach to automatically learn the tumor-related areas of PET images and weaken the irrelevant area. Then, the segmentation results of PET branch are processed to optimize the segmentation results of CT branch by using attention mechanism. The proposed neural network (MSRA-Net) can effectively fuse PET image and CT image, which can improve the precision of tumor segmentation by using complementary information of the multi-modal image, and reduce the uncertainty of single modal image segmentation. Proposed model uses multi-scale attention mechanism and residual module, which fuse multi-scale features to form complementary features of different scales. We compare with state-of-the-art medical image segmentation methods. The experiment showed that the Dice coefficient of the proposed network in soft tissue sarcoma and lymphoma datasets increased by 8.5% and 6.1% respectively compared with UNet, showing a significant improvement.
医学图像的自动分割是计算机医学诊断领域的重要组成部分,其中肿瘤分割是医学图像分割的一个重要分支。准确的自动分割方法在医疗诊断和治疗中非常重要。正电子发射计算机断层扫描(PET)和X射线计算机断层扫描(CT)图像在医学图像分割中被广泛使用,分别帮助医生准确地定位肿瘤位置和形状等信息,提供代谢和解剖信息。目前,在医学图像分割研究中,PET/CT图像尚未得到有效结合,神经网络浅层和深层之间的互补语义信息也未得到保证。为了解决上述问题,本文提出了一种用于PET/CT肿瘤分割的多尺度残差注意力网络(MSRA-Net)。我们首先使用基于注意力融合的方法自动学习PET图像中与肿瘤相关的区域,并弱化无关区域。然后,对PET分支的分割结果进行处理,利用注意力机制优化CT分支的分割结果。所提出的神经网络(MSRA-Net)能够有效地融合PET图像和CT图像,通过多模态图像的互补信息提高肿瘤分割的精度,并降低单模态图像分割的不确定性。所提模型使用多尺度注意力机制和残差模块,融合多尺度特征以形成不同尺度的互补特征。我们与当前最先进的医学图像分割方法进行了比较。实验表明,在所提出的网络在软组织肉瘤和淋巴瘤数据集中的Dice系数分别比UNet提高了8.5%和6.1%,显示出显著的改进。