Al-Bourini Omar, Seif Amir Hosseini Ali, Biggemann Lorenz, Uhlig Annemarie, Balz Julia, Haas Laura, Voit Dirk, Lotz Joachim, Frahm Jens, Uhlig Johannes
Department of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Goettingen, Germany.
Departemtn of Urology, University Medical Center Goettingen, Goettingen, Germany.
Eur J Radiol. 2023 May;162:110783. doi: 10.1016/j.ejrad.2023.110783. Epub 2023 Mar 15.
To assess artifact burden and image quality of different MRI T1 mapping techniques of the prostate.
Participants with suspected prostate cancer (PCa) were prospectively enrolled from June-October 2022 and examined with multiparametric prostate MRI (mpMRI; 3 T scanner; T1wi, T2wi, DWI und DCE). T1 mapping was performed before and after administration of gadolinium-based contrast-agent (GBCA) using (i) a modified Look-Locker inversion (MOLLI) technique and (ii) a novel single-shot T1FLASH inversion recovery technique. T2wi, DWI, T1FLASH and MOLLI sequences were systematically examined regarding prevalence of artifacts and image quality using a 5-point Likert-Scale.
A total of n = 100 patients were included (median age: 68 years). T1FLASH maps (pre-and post-GBCA) showed metal artifacts in 7% of cases and susceptibility artifacts in 1%. For MOLLI maps, pre-GBCA metal and susceptibility artifacts were documented in 6.5% of cases each. MOLLI maps post-GBCA showed artifacts in 59% of cases resulting primarily from urinary GBCA excretion and GBCA accumulation at the bladder base (p < 0.01 versus T1FLASH post-GBCA). Image quality for T1FLASH pre-GBCA was rated at a mean 4.9+/-0.4 and for MOLLI at 4.8+/-0.6 (p = 0.14). Post-GBCA image quality was rated at a mean 4.9+/-0.4 for T1FLASH and at 3.7+/-1.1 for MOLLI (p < 0.001).
T1FLASH maps provide a fast and robust method for quantification of T1 relaxation times of the prostate. T1FLASH is suitable for T1 mapping of the prostate following administration of contrast agents, while MOLLI T1 mapping is impaired through GBCA accumulation at the bladder base leading to severe image artifacts and reduced image quality.
评估前列腺不同MRI T1映射技术的伪影负担和图像质量。
2022年6月至10月前瞻性纳入疑似前列腺癌（PCa）的参与者，并采用多参数前列腺MRI（mpMRI；3T扫描仪；T1wi、T2wi、DWI和DCE）进行检查。在注射钆基造影剂（GBCA）之前和之后，使用（i）改良的Look-Locker反转（MOLLI）技术和（ii）新型单次激发T1FLASH反转恢复技术进行T1映射。使用5点李克特量表系统检查T2wi、DWI、T1FLASH和MOLLI序列的伪影发生率和图像质量。
共纳入n = 100例患者（中位年龄：68岁）。T1FLASH图（GBCA注射前后）在7%的病例中显示金属伪影，1%的病例中显示磁化率伪影。对于MOLLI图，GBCA注射前，金属和磁化率伪影在各6.5%的病例中被记录。GBCA注射后，MOLLI图在59%的病例中显示伪影，主要是由于尿液中GBCA排泄和膀胱底部GBCA积聚所致（与GBCA注射后的T1FLASH相比，p < 0.01）。GBCA注射前T1FLASH的图像质量评分为平均4.9±0.4，MOLLI为4.8±0.6（p = 0.14）。GBCA注射后，T1FLASH的图像质量评分为平均4.9±0.4，MOLLI为3.7±1.1（p < 0.001）。
T1FLASH图为前列腺T1弛豫时间的量化提供了一种快速且可靠的方法。T1FLASH适用于注射造影剂后前列腺的T1映射，而MOLLI T1映射因膀胱底部GBCA积聚而受损，导致严重的图像伪影和图像质量下降。
