[Experimental approaches to the study of permeability of the blood-brain barrier for native autogenous proteins in chicken ontogenesis].

The composition and distribution of serum proteins in blood, brain vesicles liquid, and nervous tissue has been studied in chicken embryos at 4-20 day of incubation using electrophoresis, immunoelectrophoresis, and fluorescent antibodies. At the 4-5 day of incubation, a difference in the protein composition of brain vesicles liquid and blood serum is apparent. This indicates that the border membrane of brain vesicles plays a part of the barrier. The vessels, preventing the transport of serum proteins to the nervous tissue, which are characteristic of hematoencephalic barrier of adult animals, develop in the embryo brain at the end of incubation period.