Sonavane Pooja, Willert Karl
Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, United States.
Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, United States.
Curr Top Dev Biol. 2023;153:95-119. doi: 10.1016/bs.ctdb.2023.01.002. Epub 2023 Feb 9.
The role of Wnt signaling in stem cells has been mired in seemingly contradictory findings. On one hand, Wnt has been heralded as a self-renewal factor. On the other hand, Wnt's association with differentiation and lineage commitment is indisputable. This apparent contradiction is particularly evident in pluripotent stem cells, where Wnt promotes self-renewal as well as differentiation. To resolve this discrepancy one must delve into fundamental principles of pluripotency and gain an appreciation for the concept of pluripotency states, which exist in a continuum with intermediate metastable states, some of which have been stabilized in vitro. Wnt signaling is a critical regulator of transitions between pluripotent states. Here, we will discuss Wnt's roles in maintaining pluripotency, promoting differentiation, as well as stimulating reprogramming of somatic cells to an induced pluripotent state.
Wnt信号通路在干细胞中的作用一直深陷于看似相互矛盾的研究结果之中。一方面，Wnt被誉为一种自我更新因子。另一方面，Wnt与分化及谱系定向的关联是无可争议的。这种明显的矛盾在多能干细胞中尤为明显，在多能干细胞中，Wnt既能促进自我更新，也能促进分化。为了解决这一差异，人们必须深入探究多能性的基本原理，并理解多能性状态的概念，这些状态存在于一个连续统一体中，其中包含中间亚稳态，其中一些已在体外得到稳定。Wnt信号通路是多能状态之间转变的关键调节因子。在此，我们将讨论Wnt在维持多能性、促进分化以及刺激体细胞重编程为诱导多能状态方面的作用。
