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非酒精性脂肪性肝病的非药物管理方案:实用指南

Non-pharmacological management options for MAFLD: a practical guide.

作者信息

Stefano José Tadeu, Duarte Sebastião Mauro Bezerra, Ribeiro Leite Altikes Renato Gama, Oliveira Claudia P

机构信息

Laboratório de Gastroenterologia Clínica e Experimental LIM-07, Division of Clinical Gastroenterology and Hepatology, Hospital das Clínicas HCFMUSP, Department of Gastroenterology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Departament of Gastroenterology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

出版信息

Ther Adv Endocrinol Metab. 2023 Mar 21;14:20420188231160394. doi: 10.1177/20420188231160394. eCollection 2023.

Abstract

Lifestyle changes should be the main basis for any treatment for metabolic dysfunction-associated fatty liver disease (MAFLD), aiming to increase energy expenditure, reduce energy intake and improve the quality of nutrients consumed. As it is a multifactorial disease, approaches such as physical exercise, a better dietary pattern, and possible pharmacological intervention are shown to be more efficient when used simultaneously to the detriment of their applications. The main treatment for MAFLD is a lifestyle change consisting of diet, activity, exercise, and weight loss. The variables for training prescription such as type of physical exercise (aerobic or strength training), the weekly frequency, and the intensity most indicated for the treatment of MAFLD remain uncertain, that is, the recommendations must be adapted to the clinical conditions comorbidities, and preferences of each subject in a way individual. This review addresses recent management options for MAFLD including diet, nutrients, gut microbiota, and physical exercise.

摘要

生活方式的改变应是代谢功能障碍相关脂肪性肝病(MAFLD)任何治疗的主要基础,旨在增加能量消耗、减少能量摄入并提高所消耗营养素的质量。由于它是一种多因素疾病,体育锻炼、更好的饮食模式以及可能的药物干预等方法在同时使用时比单独应用更有效。MAFLD的主要治疗方法是生活方式的改变,包括饮食、活动、锻炼和体重减轻。用于训练处方的变量,如体育锻炼的类型(有氧运动或力量训练)、每周频率以及最适合MAFLD治疗的强度,仍然不确定,也就是说,建议必须根据每个个体的临床状况、合并症和偏好进行个性化调整。本综述探讨了MAFLD最近的管理选择,包括饮食、营养素、肠道微生物群和体育锻炼。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b4/10031614/ce5fb904ad3d/10.1177_20420188231160394-fig1.jpg

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