Khan Husnain, Ul Ain Nur, Bhatti Dujanah S, Khan Junaid
Plastic Surgery, Holy Family Hospital, Rawalpindi, PAK.
Plastic and Reconstructive Surgery, Holy Family Hospital, Rawalpindi, PAK.
Cureus. 2023 Feb 22;15(2):e35286. doi: 10.7759/cureus.35286. eCollection 2023 Feb.
Background and objective Facial aesthetics have a huge impact on how individuals view themselves and are viewed by society. The aesthetics of the face are tremendously influenced by the shape of the chin and neck. In this study, we aimed to observe the outcomes in individuals after the use of ATX-101 (deoxycholic acid injection) in an expanded safe zone for submental fullness. To ensure optimal outcomes and reduce the risk of adverse events, appropriate patient selection is the key. ATX-101 treatment may be administered in combination with hyaluronic acid fillers, botulinum toxins, cryolipolysis, and radiofrequency treatment. This is the first study of its kind to be carried out at the national level in Pakistan. Materials and methods This was a quasi-experimental study conducted at the Rawalian Burn and Reconstructive Surgery Unit, Holy Family Hospital, Rawalpindi, Pakistan for a period of nine months, from 10-1-2021 to 11-10-2021. A total of 62 patients who fulfilled the inclusion criteria were enrolled. We recorded if any complications had occurred or not. Moreover, the total number of treatment sessions, the volume of injectables used, and the interval between sessions were also documented. ATX-101 package was injected into the treatment area. Due care was taken to avoid the region of the marginal mandibular nerve. After the procedure, outcomes and complications were observed. Results In this study, patient satisfaction was reported in 59 (95.2%) patients. After the fourth session, final improvement was observed in 59 (95.16%) patients. Tenderness was found in seven (11.3%) patients, bruising was noted in four (6.5%), edema was found in seven (11.3%), numbness was noted in one (1.6%), whereas paresis and alopecia were not found in any of the patients. Conclusion Our study concluded that ATX-101 is a very useful modality with fewer complication rates and is associated with significant improvement in the expanded safe zone for submental fullness.
背景与目的 面部美学对个人如何看待自己以及如何被社会看待有着巨大影响。面部美学极大地受到下巴和颈部形状的影响。在本研究中，我们旨在观察在颏下丰满的扩大安全区域使用ATX - 101（脱氧胆酸注射液）后个体的治疗效果。为确保获得最佳效果并降低不良事件风险，合适的患者选择是关键。ATX - 101治疗可与透明质酸填充剂、肉毒杆菌毒素、冷冻溶脂和射频治疗联合使用。这是在巴基斯坦全国范围内开展的同类研究中的首例。材料与方法 这是一项在巴基斯坦拉瓦尔品第圣家族医院拉瓦利安烧伤与重建外科单元进行的准实验性研究，为期九个月，从2021年1月10日至2021年10月11日。共有62名符合纳入标准的患者入组。我们记录是否发生了任何并发症。此外，还记录了治疗疗程总数、注射剂使用量以及各疗程之间的间隔时间。将ATX - 101包装注射液注入治疗区域。注意避免下颌缘神经区域。术后观察治疗效果和并发症。结果 在本研究中，59名（95.2%）患者报告了患者满意度。在第四个疗程后，59名（95.16%）患者观察到最终改善。7名（11.3%）患者出现压痛，4名（6.5%）患者出现瘀斑，7名（11.3%）患者出现水肿，1名（1.6%）患者出现麻木，而所有患者均未出现轻瘫和脱发。结论 我们的研究得出结论，ATX - 101是一种非常有用的治疗方式，并发症发生率较低，并且在颏下丰满的扩大安全区域能带来显著改善。
