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改良帕罗莫手术是改善精索静脉曲张患者血清睾酮水平和精液参数的有效干预措施:一项前瞻性研究。

Modified Palomo Procedure Is an Effective Intervention for Improving Serum Testosterone Levels and Semen Parameters in Patients With Varicocele: A Prospective Study.

作者信息

Kalwaniya Dheer S, Tolat Aditya, Kumar Devender, Naga Rohith Vakulabharanam

机构信息

General Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, IND.

General Surgery, Safdarjung Hospital, New Delhi, IND.

出版信息

Cureus. 2023 Feb 21;15(2):e35252. doi: 10.7759/cureus.35252. eCollection 2023 Feb.

Abstract

BACKGROUND

A varicocele can be defined as an abnormal venous dilatation and/or tortuosity of the pampiniform plexus. It is generally reported that varicoceles are present in 15% of the general male population and 35% of men as a cause of primary infertility and in up to 80% of men as a cause of secondary infertility. Differences in venous drainage anatomy between the left and right internal spermatic veins, venous valve incompetence resulting in venous blood reflux, and increased hydrostatic pressure are the most commonly cited theories. Various surgical and non-surgical techniques are in use for treating patients with varicocele. Here we used a modified Palamo procedure to treat the patients and observed the outcome.

METHODOLOGY

A total of 40 patients with varicocele were recruited for the study. A preoperative evaluation, along with serum testosterone levels and semen analysis, was done. A modified Palomo technique was used to treat varicocele. A postoperative follow-up with serum testosterone levels and semen analysis was done to observe improvement.

RESULTS

The mean (±SD) left testis size, right testis size, testosterone, sperm concentration, sperm vitality and sperm progressive motility were found statistically significantly higher in patients after surgery as compared to patients before surgery (p<0.05). However, there was statistically insignificant mean difference in semen volume between patients before surgery and patients after surgery (p>0.05).

CONCLUSION

Modified Palomo procedure can be used to treat varicocele with good improvement in serum testosterone levels and semen parameters.

摘要

背景

精索静脉曲张可定义为蔓状静脉丛的异常静脉扩张和/或迂曲。一般报道称,精索静脉曲张在普通男性人群中的发生率为15%,在导致原发性不育的男性中占35%,在导致继发性不育的男性中高达80%。左、右精索内静脉之间静脉引流解剖结构的差异、静脉瓣膜功能不全导致静脉血反流以及静水压力升高是最常被提及的理论。目前有多种手术和非手术技术用于治疗精索静脉曲张患者。在此,我们采用改良的帕拉莫手术治疗患者并观察其结果。

方法

本研究共招募了40例精索静脉曲张患者。进行了术前评估,包括血清睾酮水平和精液分析。采用改良的帕拉莫技术治疗精索静脉曲张。术后进行血清睾酮水平和精液分析的随访以观察改善情况。

结果

与术前相比,术后患者的左侧睾丸平均(±标准差)大小、右侧睾丸大小、睾酮、精子浓度、精子活力和精子前向运动能力在统计学上均显著升高(p<0.05)。然而,术前和术后患者的精液量在统计学上差异无显著性(p>0.05)。

结论

改良的帕拉莫手术可用于治疗精索静脉曲张,能使血清睾酮水平和精液参数得到良好改善。

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